ID   THCR_RHOER              Reviewed;         332 AA.
AC   P43462;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable thc operon regulatory protein;
GN   Name=thcR;
OS   Rhodococcus erythropolis (Arthrobacter picolinophilus).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus;
OC   Rhodococcus erythropolis group.
OX   NCBI_TaxID=1833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NI86/21;
RX   PubMed=7836301; DOI=10.1128/jb.177.3.676-687.1995;
RA   Nagy I., Schoofs G., Compernolle F., Proost P., Vanderleyden J., de Mot R.;
RT   "Degradation of the thiocarbamate herbicide EPTC (S-ethyl
RT   dipropylcarbamothioate) and biosafening by Rhodococcus sp. strain NI86/21
RT   involve an inducible cytochrome P-450 system and aldehyde dehydrogenase.";
RL   J. Bacteriol. 177:676-687(1995).
CC   -!- FUNCTION: Probably involved in the positive regulation of the thc
CC       operon for the degradation of the thiocarbamate herbicide EPTC.
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DR   EMBL; U17130; AAC45748.1; -; Genomic_DNA.
DR   AlphaFoldDB; P43462; -.
DR   SMR; P43462; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR035418; AraC-bd_2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   Pfam; PF14525; AraC_binding_2; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..332
FT                   /note="Probable thc operon regulatory protein"
FT                   /id="PRO_0000194589"
FT   DOMAIN          227..328
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        244..265
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        295..318
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   332 AA;  36919 MW;  6E557BFBC0F14340 CRC64;
     MSEDPDRGNG TKTYLSDDID EARAIGSDLY YPHEVRVLGD EHIFQMRMTA ASFGPVTLGR
     LDYSTEVEIF TNELRDSYHV NIPMRGELVT GSGRARTVAT PHRAAVYRCD QRTLLRGWAS
     PYPTPVLALK IDRRALEDQL AARLGSEIVD PIVFGMDLDL DTVVGRQWLS LVEGLSHQLD
     SPEALALHPI VSTPMAECLM SGLLVAAEHD YRARLYEPKP ALPGIVRLAV DYLEAHAQQP
     LTVAQVARNV GVSVRSLQVG FQNSLGTTPM RQLKIIRMQK ARKDLLRADP ASEGVTEIAQ
     RWGFLHVGRF AGEYKQTFGV SPSEDLRTVP FR