ID   BRK12_ASCTR             Reviewed;          12 AA.
AC   P84823;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   07-APR-2021, entry version 24.
DE   RecName: Full=Bradykinin-like peptide AV-12;
OS   Ascaphus truei (Coastal tailed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Ascaphidae; Ascaphus.
OX   NCBI_TaxID=8439;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:15922344};
RX   PubMed=15922344; DOI=10.1016/j.ygcen.2005.04.006;
RA   Conlon J.M., Jouenne T., Cosette P., Cosquer D., Vaudry H., Taylor C.K.,
RA   Abel P.W.;
RT   "Bradykinin-related peptides and tryptophyllins in the skin secretions of
RT   the most primitive extant frog, Ascaphus truei.";
RL   Gen. Comp. Endocrinol. 143:193-199(2005).
CC   -!- FUNCTION: Induces relaxation of mouse trachea that has been
CC       precontracted with methacholine. May induce relaxation of arterial
CC       smooth muscle. May target bradykinin receptors (BDKRB).
CC       {ECO:0000269|PubMed:15922344}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15922344}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:15922344}.
CC   -!- MASS SPECTROMETRY: Mass=1237.7; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15922344};
CC   -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IDA:UniProtKB.
DR   GO; GO:0006952; P:defense response; IDA:UniProtKB.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing;
KW   G-protein coupled receptor impairing toxin; Secreted; Toxin; Vasoactive;
KW   Vasodilator.
FT   PEPTIDE         1..12
FT                   /note="Bradykinin-like peptide AV-12"
FT                   /evidence="ECO:0000269|PubMed:15922344"
FT                   /id="PRO_0000233938"
SQ   SEQUENCE   12 AA;  1238 MW;  2C801F49D275B728 CRC64;
     APVPGLSPFR VV