THEGL_HUMAN
ID THEGL_HUMAN Reviewed; 465 AA.
AC P0DJG4;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Testicular haploid expressed gene protein-like;
DE AltName: Full=Theg spermatid-like protein;
GN Name=THEGL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 85-314 AND 315-443.
RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT human.";
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AC108215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DY655427; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; DW009623; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS58899.1; -.
DR RefSeq; NP_001243404.1; NM_001256475.1.
DR AlphaFoldDB; P0DJG4; -.
DR BioGRID; 1528470; 1.
DR STRING; 9606.ENSP00000456850; -.
DR iPTMnet; P0DJG4; -.
DR PhosphoSitePlus; P0DJG4; -.
DR BioMuta; THEGL; -.
DR DMDM; 384951201; -.
DR MassIVE; P0DJG4; -.
DR PaxDb; P0DJG4; -.
DR PeptideAtlas; P0DJG4; -.
DR PRIDE; P0DJG4; -.
DR ProteomicsDB; 52547; -.
DR Antibodypedia; 76754; 4 antibodies from 4 providers.
DR DNASU; 100506564; -.
DR Ensembl; ENST00000512175.3; ENSP00000456850.1; ENSG00000249693.3.
DR GeneID; 100506564; -.
DR KEGG; hsa:100506564; -.
DR MANE-Select; ENST00000512175.3; ENSP00000456850.1; NM_001256475.2; NP_001243404.1.
DR UCSC; uc031seh.2; human.
DR CTD; 100506564; -.
DR GeneCards; THEGL; -.
DR HGNC; HGNC:43771; THEGL.
DR HPA; ENSG00000249693; Tissue enriched (testis).
DR neXtProt; NX_P0DJG4; -.
DR OpenTargets; ENSG00000249693; -.
DR VEuPathDB; HostDB:ENSG00000249693; -.
DR eggNOG; ENOG502S0I9; Eukaryota.
DR GeneTree; ENSGT00940000154630; -.
DR HOGENOM; CLU_587870_0_0_1; -.
DR InParanoid; P0DJG4; -.
DR OMA; HIVYYDP; -.
DR OrthoDB; 1209550at2759; -.
DR PhylomeDB; P0DJG4; -.
DR TreeFam; TF329290; -.
DR PathwayCommons; P0DJG4; -.
DR SignaLink; P0DJG4; -.
DR BioGRID-ORCS; 100506564; 8 hits in 1052 CRISPR screens.
DR ChiTaRS; THEGL; human.
DR Pharos; P0DJG4; Tdark.
DR PRO; PR:P0DJG4; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; P0DJG4; protein.
DR Bgee; ENSG00000249693; Expressed in left testis and 47 other tissues.
DR InterPro; IPR006623; THEG.
DR InterPro; IPR042401; THEG-like.
DR PANTHER; PTHR15901; PTHR15901; 1.
DR Pfam; PF14912; THEG; 4.
DR SMART; SM00705; THEG; 7.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat.
FT CHAIN 1..465
FT /note="Testicular haploid expressed gene protein-like"
FT /id="PRO_0000416826"
FT REPEAT 174..192
FT /note="THEG 1"
FT REPEAT 214..233
FT /note="THEG 2"
FT REPEAT 260..279
FT /note="THEG 3"
FT REPEAT 297..316
FT /note="THEG 4"
FT REPEAT 333..352
FT /note="THEG 5"
FT REPEAT 373..392
FT /note="THEG 6"
FT REPEAT 409..428
FT /note="THEG 7"
FT REPEAT 446..465
FT /note="THEG 8"
FT REGION 1..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 220
FT /note="L -> Q (in Ref. 1; DW009623)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 465 AA; 53028 MW; F7F977C755B466EB CRC64;
MENQEFLSSS APSEVTDGQV STEISTCSEV FQKPIVLRIL DTHRELEESE DPEKHENPEE
PEEVREQDQR DESEECDEPH ESYEPHAPYA PHKPRDSYAP YELHGPHAAP KLLKAREPRQ
LRHTREPRKS REAKETELLP SAAVMISPSL ITRAPPRPQL SFLGANPVSC DFVRKCFSSR
KRTPNLSKPK KQWGTPDRKL FWGNQDPIRP VSQGALKAQL TKRLENLAQP KEVSCHYVPN
RAQYYHSCGR ESVIWEITPP ALFRQPSKRI QRLSQPNGFK RQCLLNRPFS DNSARDSLRI
SDPSPRILQL SVAKGTDPNY HPSKKMQTKI SLSTLSAIAT PRIIELAHPR IKLEGLCYER
QRSELPIRPV PPAAMIAKPS PRTIALAKSK SVHQDYLPDR DAHWPVSYAT THSKASPRIQ
ELANPNKRAP VRIVYYDPDV FKTKPAALKA QCSQRIWELS QPLTR
