THEM6_HUMAN
ID THEM6_HUMAN Reviewed; 208 AA.
AC Q8WUY1; B2RDN6; Q8NBN2; Q9NYI2;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Protein THEM6;
DE AltName: Full=Mesenchymal stem cell protein DSCD75;
DE AltName: Full=Thioesterase superfamily member 6;
DE Flags: Precursor;
GN Name=THEM6; Synonyms=C8orf55; ORFNames=PSEC0098;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mesenchymal stem cell;
RA van den Bos C., Mbalaviele G., Thiede M.;
RT "cDNA DSCD75 expressed by osteogenic human mesenchymal stem cells.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-93.
RC TISSUE=Muscle, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-199, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the THEM6 family. {ECO:0000305}.
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DR EMBL; AF242773; AAF65450.1; -; mRNA.
DR EMBL; AK315614; BAG37983.1; -; mRNA.
DR EMBL; AK075407; BAC11600.1; -; mRNA.
DR EMBL; BC001311; AAH01311.1; -; mRNA.
DR EMBL; BC019104; AAH19104.1; -; mRNA.
DR CCDS; CCDS6386.1; -.
DR RefSeq; NP_057731.1; NM_016647.2.
DR AlphaFoldDB; Q8WUY1; -.
DR SMR; Q8WUY1; -.
DR BioGRID; 119484; 128.
DR IntAct; Q8WUY1; 20.
DR MINT; Q8WUY1; -.
DR STRING; 9606.ENSP00000338607; -.
DR GlyGen; Q8WUY1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8WUY1; -.
DR PhosphoSitePlus; Q8WUY1; -.
DR SwissPalm; Q8WUY1; -.
DR BioMuta; THEM6; -.
DR DMDM; 146286068; -.
DR EPD; Q8WUY1; -.
DR jPOST; Q8WUY1; -.
DR MassIVE; Q8WUY1; -.
DR MaxQB; Q8WUY1; -.
DR PaxDb; Q8WUY1; -.
DR PeptideAtlas; Q8WUY1; -.
DR PRIDE; Q8WUY1; -.
DR ProteomicsDB; 74721; -.
DR Antibodypedia; 14531; 101 antibodies from 16 providers.
DR DNASU; 51337; -.
DR Ensembl; ENST00000336138.4; ENSP00000338607.3; ENSG00000130193.8.
DR GeneID; 51337; -.
DR KEGG; hsa:51337; -.
DR MANE-Select; ENST00000336138.4; ENSP00000338607.3; NM_016647.3; NP_057731.1.
DR UCSC; uc003yww.2; human.
DR CTD; 51337; -.
DR DisGeNET; 51337; -.
DR GeneCards; THEM6; -.
DR HGNC; HGNC:29656; THEM6.
DR HPA; ENSG00000130193; Low tissue specificity.
DR neXtProt; NX_Q8WUY1; -.
DR OpenTargets; ENSG00000130193; -.
DR PharmGKB; PA142672318; -.
DR VEuPathDB; HostDB:ENSG00000130193; -.
DR eggNOG; KOG4366; Eukaryota.
DR GeneTree; ENSGT00390000004859; -.
DR HOGENOM; CLU_091107_0_1_1; -.
DR InParanoid; Q8WUY1; -.
DR OMA; RDIDMCH; -.
DR OrthoDB; 1195870at2759; -.
DR PhylomeDB; Q8WUY1; -.
DR TreeFam; TF324625; -.
DR PathwayCommons; Q8WUY1; -.
DR SignaLink; Q8WUY1; -.
DR BioGRID-ORCS; 51337; 8 hits in 1076 CRISPR screens.
DR ChiTaRS; THEM6; human.
DR GenomeRNAi; 51337; -.
DR Pharos; Q8WUY1; Tdark.
DR PRO; PR:Q8WUY1; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8WUY1; protein.
DR Bgee; ENSG00000130193; Expressed in right lobe of liver and 109 other tissues.
DR ExpressionAtlas; Q8WUY1; baseline and differential.
DR Genevisible; Q8WUY1; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR029069; HotDog_dom_sf.
DR SUPFAM; SSF54637; SSF54637; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..208
FT /note="Protein THEM6"
FT /id="PRO_0000285636"
FT MOD_RES 199
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT VARIANT 93
FT /note="E -> Q (in dbSNP:rs17851711)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_032034"
FT CONFLICT 20
FT /note="D -> G (in Ref. 3; BAC11600)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 208 AA; 23865 MW; 6F9808DB345194D5 CRC64;
MLGLLVALLA LGLAVFALLD VWYLVRLPCA VLRARLLQPR VRDLLAEQRF PGRVLPSDLD
LLLHMNNARY LREADFARVA HLTRCGVLGA LRELRAHTVL AASCARHRRS LRLLEPFEVR
TRLLGWDDRA FYLEARFVSL RDGFVCALLR FRQHLLGTSP ERVVQHLCQR RVEPPELPAD
LQHWISYNEA SSQLLRMESG LSDVTKDQ
