ID   THEM6_MOUSE             Reviewed;         207 AA.
AC   Q80ZW2;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Protein THEM6;
DE   Flags: Precursor;
GN   Name=Them6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Heart, Kidney, Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the THEM6 family. {ECO:0000305}.
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DR   EMBL; BC047266; AAH47266.1; -; mRNA.
DR   CCDS; CCDS27527.1; -.
DR   RefSeq; NP_941009.1; NM_198607.1.
DR   AlphaFoldDB; Q80ZW2; -.
DR   SMR; Q80ZW2; -.
DR   BioGRID; 230161; 8.
DR   IntAct; Q80ZW2; 7.
DR   STRING; 10090.ENSMUSP00000069692; -.
DR   GlyGen; Q80ZW2; 1 site.
DR   iPTMnet; Q80ZW2; -.
DR   PhosphoSitePlus; Q80ZW2; -.
DR   SwissPalm; Q80ZW2; -.
DR   EPD; Q80ZW2; -.
DR   jPOST; Q80ZW2; -.
DR   MaxQB; Q80ZW2; -.
DR   PaxDb; Q80ZW2; -.
DR   PeptideAtlas; Q80ZW2; -.
DR   PRIDE; Q80ZW2; -.
DR   ProteomicsDB; 262775; -.
DR   Antibodypedia; 14531; 101 antibodies from 16 providers.
DR   Ensembl; ENSMUST00000070923; ENSMUSP00000069692; ENSMUSG00000056665.
DR   GeneID; 223626; -.
DR   KEGG; mmu:223626; -.
DR   UCSC; uc007wfs.1; mouse.
DR   CTD; 51337; -.
DR   MGI; MGI:1925301; Them6.
DR   VEuPathDB; HostDB:ENSMUSG00000056665; -.
DR   eggNOG; KOG4366; Eukaryota.
DR   GeneTree; ENSGT00390000004859; -.
DR   HOGENOM; CLU_091107_0_1_1; -.
DR   InParanoid; Q80ZW2; -.
DR   OMA; RDIDMCH; -.
DR   OrthoDB; 1260385at2759; -.
DR   PhylomeDB; Q80ZW2; -.
DR   TreeFam; TF324625; -.
DR   BioGRID-ORCS; 223626; 2 hits in 71 CRISPR screens.
DR   PRO; PR:Q80ZW2; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q80ZW2; protein.
DR   Bgee; ENSMUSG00000056665; Expressed in interventricular septum and 75 other tissues.
DR   Genevisible; Q80ZW2; MM.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   SUPFAM; SSF54637; SSF54637; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..207
FT                   /note="Protein THEM6"
FT                   /id="PRO_0000285637"
FT   MOD_RES         199
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WUY1"
FT   CARBOHYD        188
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   207 AA;  23803 MW;  26CF2FA726955063 CRC64;
     MLELLVASLS LALAFFALLD GWYLVRVPCA VLRARLLQPR VRDLLAEQRY AGRVLPSDLD
     LLLHMNNARY LREADVARAA HLTRCGVLGA LRDLNAHTVL AASCARYRRS LRLFEPFEVH
     TRLQGWDDRA FYLEARFVSL RDGFVCALLR FRQHVLGTSP DRVVQHLCKR RVEPPELPED
     LKHWISYNET SSQLLRAESG LSDRKDQ