ID   BRK1_BOMOR              Reviewed;         167 AA.
AC   P83060; Q90W16;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2002, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Kininogen-1;
DE   AltName: Full=BOK-1;
DE   Contains:
DE     RecName: Full=Bradykinin;
DE   Flags: Precursor;
OS   Bombina orientalis (Oriental fire-bellied toad).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Bombinatoridae; Bombina.
OX   NCBI_TaxID=8346 {ECO:0000305};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-59; 79-87; 107-115 AND
RP   135-143, AND CHARACTERIZATION.
RC   TISSUE=Skin, and Skin secretion;
RX   PubMed=12217414; DOI=10.1016/s0196-9781(02)00095-5;
RA   Chen T., Orr D.F., Bjourson A.J., McClean S., O'Rourke M., Hirst D.G.,
RA   Rao P., Shaw C.;
RT   "Bradykinins and their precursor cDNAs from the skin of the fire-bellied
RT   toad (Bombina orientalis).";
RL   Peptides 23:1547-1555(2002).
CC   -!- FUNCTION: Vasodilator. Bradykinin produces in vitro relaxation of rat
CC       arterial smooth muscle and constriction of intestinal smooth muscle.
CC       May target bradykinin receptors (BDKRB).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC       {ECO:0000305}.
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DR   EMBL; AJ316578; CAC69834.1; -; mRNA.
DR   PIR; A61361; A61361.
DR   AlphaFoldDB; P83060; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR   InterPro; IPR009608; Bradykinin.
DR   Pfam; PF06753; Bradykinin; 4.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing;
KW   G-protein coupled receptor impairing toxin; Repeat; Secreted; Signal;
KW   Toxin; Vasoactive; Vasodilator.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..167
FT                   /note="Kininogen-1"
FT                   /id="PRO_0000003429"
FT   PEPTIDE         51..59
FT                   /note="Bradykinin"
FT                   /id="PRO_0000003430"
FT   PEPTIDE         79..87
FT                   /note="Bradykinin"
FT                   /id="PRO_0000003431"
FT   PEPTIDE         107..115
FT                   /note="Bradykinin"
FT                   /id="PRO_0000003432"
FT   PEPTIDE         135..143
FT                   /note="Bradykinin"
FT                   /id="PRO_0000003433"
SQ   SEQUENCE   167 AA;  19753 MW;  CBEB4CAF3F001A9F CRC64;
     MRLWFCLSFF IILCLEHFPG TLADERNVPE SEEKTEQFLR DLSEISRLQR RPPGFSPFRG
     KFHSQSLRDL SEISRLQRRP PGFSPFRGKF HSQSMRDLSE ISRLQRRPPG FSPFRGKFHS
     QSMRDLSEIS RLQRRPPGFS PFRGKFHSQS LRGLSEIKRL KTTHKIH