ID   BRK1_DANRE              Reviewed;          75 AA.
AC   Q6IQ86;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Probable protein BRICK1;
GN   Name=brk1; ORFNames=zgc:86903;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in regulation of actin and microtubule organization.
CC       Part of a WAVE complex that activates the Arp2/3 complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRK1 family. {ECO:0000305}.
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DR   EMBL; BC071524; AAH71524.1; -; mRNA.
DR   RefSeq; NP_001002097.1; NM_001002097.1.
DR   RefSeq; XP_005172960.1; XM_005172903.3.
DR   AlphaFoldDB; Q6IQ86; -.
DR   SMR; Q6IQ86; -.
DR   STRING; 7955.ENSDARP00000061519; -.
DR   PaxDb; Q6IQ86; -.
DR   Ensembl; ENSDART00000124935; ENSDARP00000112352; ENSDARG00000041974.
DR   Ensembl; ENSDART00000184229; ENSDARP00000152289; ENSDARG00000041974.
DR   GeneID; 415187; -.
DR   KEGG; dre:415187; -.
DR   CTD; 55845; -.
DR   ZFIN; ZDB-GENE-040625-77; brk1.
DR   eggNOG; ENOG502S3PY; Eukaryota.
DR   GeneTree; ENSGT00940000170109; -.
DR   HOGENOM; CLU_175202_0_0_1; -.
DR   InParanoid; Q6IQ86; -.
DR   OMA; MPCCCWE; -.
DR   OrthoDB; 1579787at2759; -.
DR   PhylomeDB; Q6IQ86; -.
DR   TreeFam; TF324876; -.
DR   Reactome; R-DRE-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR   Reactome; R-DRE-4420097; VEGFA-VEGFR2 Pathway.
DR   Reactome; R-DRE-5663213; RHO GTPases Activate WASPs and WAVEs.
DR   Reactome; R-DRE-9013149; RAC1 GTPase cycle.
DR   Reactome; R-DRE-9013404; RAC2 GTPase cycle.
DR   Reactome; R-DRE-9013423; RAC3 GTPase cycle.
DR   PRO; PR:Q6IQ86; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 11.
DR   Bgee; ENSDARG00000041974; Expressed in brain and 26 other tissues.
DR   ExpressionAtlas; Q6IQ86; baseline.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0031209; C:SCAR complex; IBA:GO_Central.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR   GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR   GO; GO:0048870; P:cell motility; IBA:GO_Central.
DR   GO; GO:0008064; P:regulation of actin polymerization or depolymerization; IBA:GO_Central.
DR   InterPro; IPR033378; BRICK1.
DR   PANTHER; PTHR33668; PTHR33668; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..75
FT                   /note="Probable protein BRICK1"
FT                   /id="PRO_0000283648"
FT   COILED          41..72
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   75 AA;  8731 MW;  637B5476A9B4C457 CRC64;
     MAGQEDPVQR EIHQDWANRE YIEVITSSIK KIADFLNSFD MSCRSRLATL NEKLTALERR
     IEYIEARVTK GETLT