BRK1_HUMAN
ID BRK1_HUMAN Reviewed; 75 AA.
AC Q8WUW1; B2R5E2; Q9P082;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Protein BRICK1;
DE Short=BRK1;
GN Name=BRK1; Synonyms=C3orf10; ORFNames=HSPC300, MDS027;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain, and Lung;
RA Xu Q., Duan R., Huo Y., Fan B., Zhang K., Wu D.;
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Umbilical cord blood;
RA Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L.,
RA Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.;
RT "Human partial CDS from CD34+ stem cells.";
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung, and Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INTERACTION WITH WASF2.
RX PubMed=15070726; DOI=10.1073/pnas.0400628101;
RA Gautreau A., Ho H.-Y., Li J., Steen H., Gygi S.P., Kirschner M.W.;
RT "Purification and architecture of the ubiquitous Wave complex.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:4379-4383(2004).
RN [7]
RP FUNCTION, AND SUBUNIT.
RX PubMed=18560548; DOI=10.1371/journal.pone.0002462;
RA Derivery E., Fink J., Martin D., Houdusse A., Piel M., Stradal T.E.,
RA Louvard D., Gautreau A.;
RT "Free Brick1 is a trimeric precursor in the assembly of a functional wave
RT complex.";
RL PLoS ONE 3:E2462-E2462(2008).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [11]
RP X-RAY CRYSTALLOGRAPHY (2.29 ANGSTROMS) OF WAVE1 COMPLEX, AND SUBUNIT.
RX PubMed=21107423; DOI=10.1038/nature09623;
RA Chen Z., Borek D., Padrick S.B., Gomez T.S., Metlagel Z., Ismail A.M.,
RA Umetani J., Billadeau D.D., Otwinowski Z., Rosen M.K.;
RT "Structure and control of the actin regulatory WAVE complex.";
RL Nature 468:533-538(2010).
CC -!- FUNCTION: Involved in regulation of actin and microtubule organization.
CC Part of a WAVE complex that activates the Arp2/3 complex. As component
CC of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and
CC signaling from early endosomes (By similarity).
CC {ECO:0000250|UniProtKB:Q91VR8, ECO:0000269|PubMed:18560548}.
CC -!- SUBUNIT: Homotrimer when in free form. Directly interacts with WASF2.
CC Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2,
CC BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer
CC containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by
CC WAVE1, ABI2 and BRK1. {ECO:0000269|PubMed:15070726,
CC ECO:0000269|PubMed:18560548, ECO:0000269|PubMed:21107423}.
CC -!- INTERACTION:
CC Q8WUW1; P01023: A2M; NbExp=3; IntAct=EBI-2837444, EBI-640741;
CC Q8WUW1; Q99996-3: AKAP9; NbExp=3; IntAct=EBI-2837444, EBI-11022349;
CC Q8WUW1; Q99700-5: ATXN2; NbExp=3; IntAct=EBI-2837444, EBI-25891409;
CC Q8WUW1; P46379-2: BAG6; NbExp=3; IntAct=EBI-2837444, EBI-10988864;
CC Q8WUW1; O14874-2: BCKDK; NbExp=3; IntAct=EBI-2837444, EBI-25895587;
CC Q8WUW1; Q0VDD7: BRME1; NbExp=3; IntAct=EBI-2837444, EBI-741210;
CC Q8WUW1; Q9H5F2: C11orf1; NbExp=3; IntAct=EBI-2837444, EBI-718615;
CC Q8WUW1; Q9BRT8: CBWD1; NbExp=3; IntAct=EBI-2837444, EBI-1054417;
CC Q8WUW1; Q8TAB7: CCDC26; NbExp=3; IntAct=EBI-2837444, EBI-10271580;
CC Q8WUW1; P40227: CCT6A; NbExp=3; IntAct=EBI-2837444, EBI-356687;
CC Q8WUW1; Q7L3B6: CDC37L1; NbExp=3; IntAct=EBI-2837444, EBI-2841876;
CC Q8WUW1; P09172: DBH; NbExp=3; IntAct=EBI-2837444, EBI-8589586;
CC Q8WUW1; Q14203-5: DCTN1; NbExp=3; IntAct=EBI-2837444, EBI-25840379;
CC Q8WUW1; G5E9A7: DMWD; NbExp=3; IntAct=EBI-2837444, EBI-10976677;
CC Q8WUW1; P50570-2: DNM2; NbExp=3; IntAct=EBI-2837444, EBI-10968534;
CC Q8WUW1; Q86TI2-2: DPP9; NbExp=3; IntAct=EBI-2837444, EBI-21529239;
CC Q8WUW1; Q96EV8: DTNBP1; NbExp=3; IntAct=EBI-2837444, EBI-465804;
CC Q8WUW1; P26641: EEF1G; NbExp=3; IntAct=EBI-2837444, EBI-351467;
CC Q8WUW1; P14136: GFAP; NbExp=3; IntAct=EBI-2837444, EBI-744302;
CC Q8WUW1; P28799: GRN; NbExp=3; IntAct=EBI-2837444, EBI-747754;
CC Q8WUW1; O75506: HSBP1; NbExp=6; IntAct=EBI-2837444, EBI-748664;
CC Q8WUW1; P42858: HTT; NbExp=6; IntAct=EBI-2837444, EBI-466029;
CC Q8WUW1; Q8IY31-3: IFT20; NbExp=3; IntAct=EBI-2837444, EBI-9091197;
CC Q8WUW1; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-2837444, EBI-1055254;
CC Q8WUW1; O60333-2: KIF1B; NbExp=3; IntAct=EBI-2837444, EBI-10975473;
CC Q8WUW1; O14901: KLF11; NbExp=3; IntAct=EBI-2837444, EBI-948266;
CC Q8WUW1; Q15012: LAPTM4A; NbExp=3; IntAct=EBI-2837444, EBI-723416;
CC Q8WUW1; Q8N7X4: MAGEB6; NbExp=3; IntAct=EBI-2837444, EBI-6447163;
CC Q8WUW1; P51608: MECP2; NbExp=3; IntAct=EBI-2837444, EBI-1189067;
CC Q8WUW1; O95563: MPC2; NbExp=3; IntAct=EBI-2837444, EBI-719403;
CC Q8WUW1; Q9Y605: MRFAP1; NbExp=6; IntAct=EBI-2837444, EBI-995714;
CC Q8WUW1; Q9GZM8: NDEL1; NbExp=7; IntAct=EBI-2837444, EBI-928842;
CC Q8WUW1; P19404: NDUFV2; NbExp=3; IntAct=EBI-2837444, EBI-713665;
CC Q8WUW1; O00746: NME4; NbExp=3; IntAct=EBI-2837444, EBI-744871;
CC Q8WUW1; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-2837444, EBI-2811583;
CC Q8WUW1; Q96FW1: OTUB1; NbExp=3; IntAct=EBI-2837444, EBI-1058491;
CC Q8WUW1; P41231: P2RY2; NbExp=3; IntAct=EBI-2837444, EBI-8677294;
CC Q8WUW1; O15534: PER1; NbExp=3; IntAct=EBI-2837444, EBI-2557276;
CC Q8WUW1; Q5T6S3: PHF19; NbExp=3; IntAct=EBI-2837444, EBI-2339674;
CC Q8WUW1; D3DTS7: PMP22; NbExp=3; IntAct=EBI-2837444, EBI-25882629;
CC Q8WUW1; O60260-5: PRKN; NbExp=3; IntAct=EBI-2837444, EBI-21251460;
CC Q8WUW1; O14744: PRMT5; NbExp=3; IntAct=EBI-2837444, EBI-351098;
CC Q8WUW1; P41219: PRPH; NbExp=3; IntAct=EBI-2837444, EBI-752074;
CC Q8WUW1; Q8TAS3: PRRG2; NbExp=3; IntAct=EBI-2837444, EBI-10272071;
CC Q8WUW1; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-2837444, EBI-396669;
CC Q8WUW1; Q5VTR2: RNF20; NbExp=3; IntAct=EBI-2837444, EBI-2372238;
CC Q8WUW1; Q8N488: RYBP; NbExp=3; IntAct=EBI-2837444, EBI-752324;
CC Q8WUW1; P37840: SNCA; NbExp=3; IntAct=EBI-2837444, EBI-985879;
CC Q8WUW1; O95238: SPDEF; NbExp=3; IntAct=EBI-2837444, EBI-12811275;
CC Q8WUW1; Q8TCT7-2: SPPL2B; NbExp=3; IntAct=EBI-2837444, EBI-8345366;
CC Q8WUW1; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-2837444, EBI-5235340;
CC Q8WUW1; O60220: TIMM8A; NbExp=3; IntAct=EBI-2837444, EBI-1049822;
CC Q8WUW1; Q3KNT9: TMEM95; NbExp=3; IntAct=EBI-2837444, EBI-12892569;
CC Q8WUW1; P68363-2: TUBA1B; NbExp=3; IntAct=EBI-2837444, EBI-25895616;
CC Q8WUW1; P61086: UBE2K; NbExp=3; IntAct=EBI-2837444, EBI-473850;
CC Q8WUW1; P09936: UCHL1; NbExp=3; IntAct=EBI-2837444, EBI-714860;
CC Q8WUW1; P45880: VDAC2; NbExp=3; IntAct=EBI-2837444, EBI-354022;
CC Q8WUW1; Q8N0U8: VKORC1L1; NbExp=3; IntAct=EBI-2837444, EBI-11337915;
CC Q8WUW1; Q8TCV5: WFDC5; NbExp=3; IntAct=EBI-2837444, EBI-12175871;
CC Q8WUW1; O43257: ZNHIT1; NbExp=3; IntAct=EBI-2837444, EBI-347522;
CC Q8WUW1; Q86V28; NbExp=3; IntAct=EBI-2837444, EBI-10259496;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WUW1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WUW1-2; Sequence=VSP_024350;
CC -!- SIMILARITY: Belongs to the BRK1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF28978.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY148219; AAN60161.1; -; mRNA.
DR EMBL; AY148220; AAN60162.1; -; mRNA.
DR EMBL; AF161418; AAF28978.1; ALT_INIT; mRNA.
DR EMBL; AK312155; BAG35089.1; -; mRNA.
DR EMBL; CH471055; EAW64061.1; -; Genomic_DNA.
DR EMBL; BC001067; AAH01067.1; -; mRNA.
DR EMBL; BC007929; AAH07929.1; -; mRNA.
DR EMBL; BC019303; AAH19303.1; -; mRNA.
DR CCDS; CCDS54553.1; -. [Q8WUW1-1]
DR RefSeq; NP_060932.2; NM_018462.4. [Q8WUW1-1]
DR PDB; 3P8C; X-ray; 2.29 A; E=1-75.
DR PDB; 4N78; X-ray; 2.43 A; E=1-75.
DR PDBsum; 3P8C; -.
DR PDBsum; 4N78; -.
DR AlphaFoldDB; Q8WUW1; -.
DR SMR; Q8WUW1; -.
DR BioGRID; 120947; 119.
DR CORUM; Q8WUW1; -.
DR DIP; DIP-41554N; -.
DR IntAct; Q8WUW1; 97.
DR MINT; Q8WUW1; -.
DR STRING; 9606.ENSP00000432472; -.
DR ChEMBL; CHEMBL3758062; -.
DR iPTMnet; Q8WUW1; -.
DR MetOSite; Q8WUW1; -.
DR PhosphoSitePlus; Q8WUW1; -.
DR BioMuta; BRK1; -.
DR DMDM; 74730773; -.
DR EPD; Q8WUW1; -.
DR jPOST; Q8WUW1; -.
DR MassIVE; Q8WUW1; -.
DR MaxQB; Q8WUW1; -.
DR PaxDb; Q8WUW1; -.
DR PeptideAtlas; Q8WUW1; -.
DR PRIDE; Q8WUW1; -.
DR ProteomicsDB; 74714; -. [Q8WUW1-1]
DR ProteomicsDB; 74715; -. [Q8WUW1-2]
DR TopDownProteomics; Q8WUW1-1; -. [Q8WUW1-1]
DR TopDownProteomics; Q8WUW1-2; -. [Q8WUW1-2]
DR Antibodypedia; 53142; 97 antibodies from 23 providers.
DR DNASU; 55845; -.
DR Ensembl; ENST00000530758.2; ENSP00000432472.1; ENSG00000254999.4. [Q8WUW1-1]
DR GeneID; 55845; -.
DR KEGG; hsa:55845; -.
DR MANE-Select; ENST00000530758.2; ENSP00000432472.1; NM_018462.5; NP_060932.2.
DR UCSC; uc003bvb.4; human. [Q8WUW1-1]
DR CTD; 55845; -.
DR DisGeNET; 55845; -.
DR GeneCards; BRK1; -.
DR HGNC; HGNC:23057; BRK1.
DR HPA; ENSG00000254999; Low tissue specificity.
DR MIM; 611183; gene.
DR neXtProt; NX_Q8WUW1; -.
DR OpenTargets; ENSG00000254999; -.
DR PharmGKB; PA134866423; -.
DR VEuPathDB; HostDB:ENSG00000254999; -.
DR eggNOG; ENOG502S3PY; Eukaryota.
DR GeneTree; ENSGT00390000011082; -.
DR HOGENOM; CLU_175202_0_0_1; -.
DR InParanoid; Q8WUW1; -.
DR OMA; MPCCCWE; -.
DR OrthoDB; 1579787at2759; -.
DR PhylomeDB; Q8WUW1; -.
DR TreeFam; TF324876; -.
DR PathwayCommons; Q8WUW1; -.
DR Reactome; R-HSA-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-HSA-4420097; VEGFA-VEGFR2 Pathway.
DR Reactome; R-HSA-5663213; RHO GTPases Activate WASPs and WAVEs.
DR Reactome; R-HSA-9013149; RAC1 GTPase cycle.
DR Reactome; R-HSA-9013404; RAC2 GTPase cycle.
DR Reactome; R-HSA-9013423; RAC3 GTPase cycle.
DR Reactome; R-HSA-9664422; FCGR3A-mediated phagocytosis.
DR SignaLink; Q8WUW1; -.
DR SIGNOR; Q8WUW1; -.
DR BioGRID-ORCS; 55845; 185 hits in 1079 CRISPR screens.
DR ChiTaRS; BRK1; human.
DR EvolutionaryTrace; Q8WUW1; -.
DR GeneWiki; C3orf10; -.
DR GenomeRNAi; 55845; -.
DR Pharos; Q8WUW1; Tbio.
DR PRO; PR:Q8WUW1; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8WUW1; protein.
DR Bgee; ENSG00000254999; Expressed in sperm and 185 other tissues.
DR Genevisible; Q8WUW1; HS.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
DR GO; GO:0031209; C:SCAR complex; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR GO; GO:0044877; F:protein-containing complex binding; IPI:UniProtKB.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR GO; GO:0048870; P:cell motility; IBA:GO_Central.
DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:2000601; P:positive regulation of Arp2/3 complex-mediated actin nucleation; IDA:UniProtKB.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0010592; P:positive regulation of lamellipodium assembly; IDA:ARUK-UCL.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IMP:UniProtKB.
DR GO; GO:0016601; P:Rac protein signal transduction; IDA:UniProtKB.
DR GO; GO:0008064; P:regulation of actin polymerization or depolymerization; IBA:GO_Central.
DR InterPro; IPR033378; BRICK1.
DR PANTHER; PTHR33668; PTHR33668; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Coiled coil; Cytoplasm;
KW Cytoskeleton; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:19413330,
FT ECO:0007744|PubMed:22814378"
FT CHAIN 2..75
FT /note="Protein BRICK1"
FT /id="PRO_0000283646"
FT COILED 41..72
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:19413330,
FT ECO:0007744|PubMed:22814378"
FT VAR_SEQ 75
FT /note="T -> TRTVPCCCWEVALHNTGHMGKAPAAFSSFLSP (in isoform
FT 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_024350"
FT HELIX 11..68
FT /evidence="ECO:0007829|PDB:3P8C"
SQ SEQUENCE 75 AA; 8745 MW; 637B5461A2D96587 CRC64;
MAGQEDPVQR EIHQDWANRE YIEIITSSIK KIADFLNSFD MSCRSRLATL NEKLTALERR
IEYIEARVTK GETLT
