ID   THIB_XENLA              Reviewed;         688 AA.
AC   Q91641;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Thyroid hormone-induced protein B;
DE   Flags: Precursor;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8700860; DOI=10.1073/pnas.93.5.1924;
RA   Brown D.D., Wang Z., Furlow J.D., Kanamori A., Schwartzman R.A., Remo B.F.,
RA   Pinder A.;
RT   "The thyroid hormone-induced tail resorption program during Xenopus laevis
RT   metamorphosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:1924-1929(1996).
CC   -!- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Secreted,
CC       extracellular space.
CC   -!- DEVELOPMENTAL STAGE: Metamorphosis; thyroid hormone-induced tail
CC       resorption.
CC   -!- INDUCTION: By thyroid hormone.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC59868.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U37376; AAC59868.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_001079067.1; NM_001085598.1.
DR   AlphaFoldDB; Q91641; -.
DR   SMR; Q91641; -.
DR   GeneID; 373599; -.
DR   KEGG; xla:373599; -.
DR   CTD; 373599; -.
DR   Xenbase; XB-GENE-864900; mamdc2.L.
DR   OrthoDB; 270113at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 373599; Expressed in stomach and 11 other tissues.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd06263; MAM; 4.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000998; MAM_dom.
DR   Pfam; PF00629; MAM; 4.
DR   SMART; SM00137; MAM; 4.
DR   SUPFAM; SSF49899; SSF49899; 4.
DR   PROSITE; PS00740; MAM_1; 2.
DR   PROSITE; PS50060; MAM_2; 4.
PE   2: Evidence at transcript level;
KW   Developmental protein; Glycoprotein; Membrane; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..688
FT                   /note="Thyroid hormone-induced protein B"
FT                   /id="PRO_0000022490"
FT   DOMAIN          26..169
FT                   /note="MAM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT   DOMAIN          170..330
FT                   /note="MAM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT   DOMAIN          341..500
FT                   /note="MAM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT   DOMAIN          509..669
FT                   /note="MAM 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT   CARBOHYD        32
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        135
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        358
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        668
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   688 AA;  77658 MW;  1FFD10FA8DFDDEC4 CRC64;
     MMLSHWVLLL SLGAVWLAEG GEISPGSCTF ENSTCAYTSA FPFLQWTVNI EGHYVSVDSS
     NGLRGQKAVL ISPDLHLAEW SCLRLVYQIA GSESSPSPSS LNVFVRPEGE SFDYLLWSAE
     EHSDSWLISS IDLKNTTKRF KIILEGVLGE NTMSSIAIFE VKMTTGYCIE CDFEENHLCG
     YMNSWNPNVN WFVGGGNVKN SHSILPRDHT LNNELGHYMY VDSVYVKHFQ EVAQLVSPLI
     ITPISGCLSF YYQLQRETSN IFLVHTRDLH GSYDEIWKMG AVRQGEWNLA EVDLNAHVPL
     EVIFEVAFNG IQAGYVALDD ILFSPVSCSG QEGMFFDARE AGCDFEEGMC QFHQDDNNGS
     GWSRVKVKPN AYQMGDHTTG LGYFMIANTR FTGQPAYFGR LYGPSLPGNI QYCIRFFYSL
     YGFYKTIDSL AVYIFEENHV VQEKIWSAHE TPKGVWLQAE ISIHKPMPFK VVFVSWCKSL
     WDCGIAALDD ISVSIGSCKI SDRIPPLPGK CTFEKNDCGF EQEWQRRGIW HRIQGRTPTF
     YTGPNGDHTS GVGYYMYIEA TNMVFGQKAK LISRPLRAVA GKQCLTFYYH MYGAGTGLLN
     VYLTKEGDIN KDTLLWTRKG EQSITWLKAQ MEYESEQQHK IVFEAVRGIS IRSDIAIDDI
     LFQNGPCNDS SDPLQSSGYS DNFNNIEF