BRK3_PHYSA
ID BRK3_PHYSA Reviewed; 9 AA.
AC P84673;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 26-FEB-2020, entry version 28.
DE RecName: Full=[Val1,Thr6]-bradykinin;
OS Phyllomedusa sauvagei (Sauvage's leaf frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC Phyllomedusa.
OX NCBI_TaxID=8395;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RC TISSUE=Skin {ECO:0000269|PubMed:14612182};
RX PubMed=14612182; DOI=10.1016/j.peptides.2003.06.002;
RA Chen T., Shaw C.;
RT "Cloning of the (Thr6)-phyllokinin precursor from Phyllomedusa sauvagei
RT skin confirms a non-consensus tyrosine 0-sulfation motif.";
RL Peptides 24:1123-1130(2003).
CC -!- FUNCTION: May produce in vitro relaxation of rat arterial smooth muscle
CC and constriction of intestinal smooth muscle. May target bradykinin
CC receptors (BDKRB).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands. {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=1059.45; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:14612182};
CC -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Direct protein sequencing;
KW G-protein coupled receptor impairing toxin; Secreted; Toxin; Vasoactive;
KW Vasodilator.
FT PEPTIDE 1..9
FT /note="[Val1,Thr6]-bradykinin"
FT /id="PRO_0000043523"
SQ SEQUENCE 9 AA; 1017 MW; 3687D771A9C86777 CRC64;
VPPGFTPFR