BRK4_PHAJA
ID BRK4_PHAJA Reviewed; 8 AA.
AC P86630;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 1.
DT 26-FEB-2020, entry version 12.
DE RecName: Full=Des-Arg9-[Thr6]-bradykinin;
DE Short=Des-Arg-[Thr6]-bradykinin {ECO:0000303|PubMed:20932854};
OS Phasmahyla jandaia (Jandaia leaf frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC Phasmahyla.
OX NCBI_TaxID=762504;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS
RP SPECTROMETRY.
RC TISSUE=Skin secretion {ECO:0000269|PubMed:20932854};
RX PubMed=20932854; DOI=10.1016/j.toxicon.2010.09.010;
RA Rates B., Silva L.P., Ireno I.C., Leite F.S., Borges M.H., Bloch C. Jr.,
RA De Lima M.E., Pimenta A.M.;
RT "Peptidomic dissection of the skin secretion of Phasmahyla jandaia
RT (Bokermann and Sazima, 1978) (Anura, Hylidae, Phyllomedusinae).";
RL Toxicon 57:35-52(2011).
CC -!- FUNCTION: Produces in vitro relaxation of rat arterial smooth muscle
CC and constriction of intestinal smooth muscle (By similarity). May
CC target bradykinin receptors (BDKRB). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20932854}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000269|PubMed:20932854}.
CC -!- MASS SPECTROMETRY: Mass=917.4; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:20932854};
CC -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Direct protein sequencing;
KW G-protein coupled receptor impairing toxin; Secreted; Toxin; Vasoactive;
KW Vasodilator.
FT PEPTIDE 1..8
FT /note="Des-Arg9-[Thr6]-bradykinin"
FT /evidence="ECO:0000269|PubMed:20932854"
FT /id="PRO_0000404633"
SQ SEQUENCE 8 AA; 918 MW; 33D771A9C8677774 CRC64;
RPPGFTPF