BRK4_PHYSG
ID BRK4_PHYSG Reviewed; 11 AA.
AC P86814;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 1.
DT 26-FEB-2020, entry version 16.
DE RecName: Full=[Ala1,Thr6]-bradykinyl-Ser,Lys {ECO:0000303|Ref.1};
OS Physalaemus signifer (Girard's dwarf frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Leptodactylidae; Leiuperinae;
OC Physalaemus.
OX NCBI_TaxID=364768;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Skin secretion {ECO:0000269|Ref.1};
RA Rates B., Ireno I.C., Canelas M.A., de Lima M.E., Pimenta A.M.C.;
RT "Bradykinin-related peptides in skin secretion of Physalaemus signifer
RT (Girard, 1853) (Anura, Leiuperidae).";
RL Submitted (SEP-2010) to UniProtKB.
CC -!- FUNCTION: Produces in vitro relaxation of rat arterial smooth muscle
CC and constriction of intestinal smooth muscle (By similarity). May
CC target bradykinin receptors (BDKRB). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands. {ECO:0000269|Ref.1}.
CC -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR InterPro; IPR009608; Bradykinin.
DR Pfam; PF06753; Bradykinin; 1.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Direct protein sequencing;
KW G-protein coupled receptor impairing toxin; Secreted; Toxin; Vasoactive;
KW Vasodilator.
FT PEPTIDE 1..11
FT /note="[Ala1,Thr6]-bradykinyl-Ser,Lys"
FT /evidence="ECO:0000269|Ref.1"
FT /id="PRO_0000404689"
SQ SEQUENCE 11 AA; 1204 MW; 3D70E40CD771A9C8 CRC64;
APPGFTPFRS K