ID   BRK4_PITAZ              Reviewed;           9 AA.
AC   P85885;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=[Hyp3]-bradykinin {ECO:0000303|PubMed:17120273};
OS   Pithecopus azureus (Orange-legged monkey tree frog) (Phyllomedusa azurea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=2034991;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND HYDROXYLATION AT PRO-3.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:17120273};
RX   PubMed=17120273; DOI=10.1002/rcm.2791;
RA   Thompson A.H., Bjourson A.J., Shaw C., McClean S.;
RT   "Bradykinin-related peptides from Phyllomedusa hypochondrialis azurea: Mass
RT   spectrometric structural characterisation and cloning of precursor cDNAs.";
RL   Rapid Commun. Mass Spectrom. 20:3780-3788(2006).
CC   -!- FUNCTION: Induces relaxation of arterial smooth muscle, by targeting
CC       bradykinin receptors (BDKRB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17120273}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:17120273}.
CC   -!- MASS SPECTROMETRY: Mass=1075.57; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:17120273};
CC   -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC       {ECO:0000305}.
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DR   SMR; P85885; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing;
KW   G-protein coupled receptor impairing toxin; Hydroxylation; Secreted; Toxin;
KW   Vasoactive; Vasodilator.
FT   PEPTIDE         1..9
FT                   /note="[Hyp3]-bradykinin"
FT                   /evidence="ECO:0000269|PubMed:17120273"
FT                   /id="PRO_0000372705"
FT   MOD_RES         3
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:17120273"
SQ   SEQUENCE   9 AA;  1060 MW;  3393D775B9C86777 CRC64;
     RPPGFSPFR