BRK6_PITHY
ID BRK6_PITHY Reviewed; 10 AA.
AC P84897;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 02-DEC-2020, entry version 23.
DE RecName: Full=[Val1,Hyp2,Thr6]-bradykinyl-Gln;
OS Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa
OS hypochondrialis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC Pithecopus.
OX NCBI_TaxID=317381;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, MASS SPECTROMETRY, AND HYDROXYLATION AT PRO-2.
RC TISSUE=Skin secretion {ECO:0000269|PubMed:16797783};
RX PubMed=16797783; DOI=10.1016/j.peptides.2006.04.020;
RA Brand G.D., Krause F.C., Silva L.P., Leite J.R.S.A., Melo J.A.T.,
RA Prates M.V., Pesquero J.B., Santos E.L., Nakaie C.R., Costa-Neto C.M.,
RA Bloch C. Jr.;
RT "Bradykinin-related peptides from Phyllomedusa hypochondrialis.";
RL Peptides 27:2137-2146(2006).
CC -!- FUNCTION: Produces in vitro relaxation of rat arterial smooth muscle
CC and constriction of intestinal smooth muscle (By similarity). May
CC target bradykinin receptors (BDKRB). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000269|PubMed:16797783}.
CC -!- MASS SPECTROMETRY: Mass=1161.65; Mass_error=0.1; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:16797783};
CC -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Direct protein sequencing;
KW G-protein coupled receptor impairing toxin; Hydroxylation; Secreted; Toxin;
KW Vasoactive; Vasodilator.
FT PEPTIDE 1..10
FT /note="[Val1,Hyp2,Thr6]-bradykinyl-Gln"
FT /evidence="ECO:0000269|PubMed:16797783"
FT /id="PRO_0000248467"
FT MOD_RES 2
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:16797783"
SQ SEQUENCE 10 AA; 1145 MW; 339687D771A9C867 CRC64;
VPPGFTPFRQ