BRK7_PITNO
ID BRK7_PITNO Reviewed; 8 AA.
AC P86427;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 09-FEB-2010, sequence version 1.
DT 26-FEB-2020, entry version 14.
DE RecName: Full=Bradykinin-related peptide Pnor-7 {ECO:0000303|Ref.1};
OS Pithecopus nordestinus (Northeastern Brazilian leaf frog) (Phyllomedusa
OS nordestina).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC Pithecopus.
OX NCBI_TaxID=2034992;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP MASS SPECTROMETRY.
RC TISSUE=Skin secretion {ECO:0000269|Ref.1};
RA Conceicao K., Bruni F.M., Sciano J.M., Konno K., Melo R.L.,
RA Antoniazzi M.M., Jared C., Lopes-Ferreira M., Pimenta D.C.;
RT "Identification of bradykinin-related peptides from Phyllomedusa nordestina
RT skin secretion using electrospray ionization tandem mass spectrometry after
RT a single-step liquid chromatography.";
RL J. Venom. Anim. Toxins Incl. Trop. Dis. 15:633-652(2009).
CC -!- FUNCTION: Vasodilator. May target bradykinin receptors (BDKRB).
CC {ECO:0000269|Ref.1}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands. {ECO:0000269|Ref.1}.
CC -!- MASS SPECTROMETRY: Mass=814.38; Method=MALDI;
CC Evidence={ECO:0000269|Ref.1};
CC -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Bradykinin receptor impairing toxin;
KW Direct protein sequencing; G-protein coupled receptor impairing toxin;
KW Secreted; Toxin; Vasoactive; Vasodilator.
FT PEPTIDE 1..8
FT /note="Bradykinin-related peptide Pnor-7"
FT /evidence="ECO:0000269|Ref.1"
FT /id="PRO_0000391419"
SQ SEQUENCE 8 AA; 814 MW; 8885A2C873277772 CRC64;
VPPKGVSM