ID   BRKF_CYPDO              Reviewed;          11 AA.
AC   P0DL32;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2013, sequence version 1.
DT   29-SEP-2021, entry version 14.
DE   RecName: Full=Fulvonin {ECO:0000303|PubMed:19716363};
DE   AltName: Full=Bradykinin-related peptide {ECO:0000303|PubMed:19716363};
OS   Cyphononyx dorsalis (Spider wasp) (Cyphononyx fulvognathus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Pompiloidea;
OC   Pompilidae; Pepsinae; Cyphononyx.
OX   NCBI_TaxID=246266;
RN   [1]
RP   PROTEIN SEQUENCE, SYNTHESIS, FUNCTION, BIOASSAY, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=19716363; DOI=10.1016/j.bcp.2009.08.020;
RA   Picolo G., Hisada M., Moura A.B., Machado M.F., Sciani J.M.,
RA   Conceicao I.M., Melo R.L., Oliveira V., Lima-Landman M.T., Cury Y.,
RA   Konno K., Hayashi M.A.;
RT   "Bradykinin-related peptides in the venom of the solitary wasp Cyphononyx
RT   fulvognathus.";
RL   Biochem. Pharmacol. 79:478-486(2010).
RN   [2]
RP   REVIEW.
RX   PubMed=27096870; DOI=10.3390/toxins8040114;
RA   Konno K., Kazuma K., Nihei K.;
RT   "Peptide toxins in solitary wasp venoms.";
RL   Toxins 8:114-114(2016).
CC   -!- FUNCTION: Inhibits angiotensin-converting enzyme (ACE) with a Ki of 1.2
CC       uM, targets B1 bradykinin receptors (BDKRB1), and potentiates the
CC       smooth muscle contraction elicited by bradykinin. In vivo, induces
CC       hyperalgesic effects in living rats after intraplantar injection.
CC       {ECO:0000269|PubMed:19716363}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=1243.8; Method=MALDI; Note=Monoisotopic mass.;
CC       Evidence={ECO:0000269|PubMed:19716363};
CC   -!- MISCELLANEOUS: Is hydrolyzed by angiotensin-converting enzyme (ACE) by
CC       only 7.5% (compared to bradykinin). {ECO:0000305|PubMed:19716363}.
CC   -!- MISCELLANEOUS: Not able to contract smooth muscle preparation (ileum).
CC       {ECO:0000305|PubMed:19716363}.
CC   -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Bradykinin receptor impairing toxin; Direct protein sequencing;
KW   G-protein coupled receptor impairing toxin; Secreted; Toxin.
FT   PEPTIDE         1..11
FT                   /note="Fulvonin"
FT                   /id="PRO_0000424141"
SQ   SEQUENCE   11 AA;  1244 MW;  5ADDBCB2D3386407 CRC64;
     SIVLRGKAPF R