ID   BRKP2_PHAJA             Reviewed;          11 AA.
AC   P86632;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   26-FEB-2020, entry version 12.
DE   RecName: Full=[Thr6]-Phyllokinin {ECO:0000303|PubMed:20932854};
OS   Phasmahyla jandaia (Jandaia leaf frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phasmahyla.
OX   NCBI_TaxID=762504;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND SULFATION AT TYR-11.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:20932854};
RX   PubMed=20932854; DOI=10.1016/j.toxicon.2010.09.010;
RA   Rates B., Silva L.P., Ireno I.C., Leite F.S., Borges M.H., Bloch C. Jr.,
RA   De Lima M.E., Pimenta A.M.;
RT   "Peptidomic dissection of the skin secretion of Phasmahyla jandaia
RT   (Bokermann and Sazima, 1978) (Anura, Hylidae, Phyllomedusinae).";
RL   Toxicon 57:35-52(2011).
CC   -!- FUNCTION: May produce in vitro relaxation of rat arterial smooth muscle
CC       and constriction of intestinal smooth muscle (By similarity). May
CC       target bradykinin receptors (BDKRB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20932854}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:20932854}.
CC   -!- MASS SPECTROMETRY: Mass=1429.8; Method=MALDI; Note=Sulfated.;
CC       Evidence={ECO:0000269|PubMed:20932854};
CC   -!- MASS SPECTROMETRY: Mass=1349.8; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20932854};
CC   -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing;
KW   G-protein coupled receptor impairing toxin; Secreted; Sulfation; Toxin;
KW   Vasoactive; Vasodilator.
FT   PEPTIDE         1..11
FT                   /note="[Thr6]-Phyllokinin"
FT                   /evidence="ECO:0000269|PubMed:20932854"
FT                   /id="PRO_0000404635"
FT   MOD_RES         11
FT                   /note="Sulfotyrosine; partial"
FT                   /evidence="ECO:0000269|PubMed:20932854"
FT   UNSURE          10
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:20932854"
SQ   SEQUENCE   11 AA;  1351 MW;  25051393D771A9C8 CRC64;
     RPPGFTPFRI Y