ID   BRKPS_AGASP             Reviewed;          62 AA.
AC   A0A5Q0MUM5;
DT   17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2020, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=[Ser6, Val10, Asp11]-phyllokinin {ECO:0000303|PubMed:31671555};
DE   Flags: Precursor;
OS   Agalychnis spurrelli (Gliding leaf frog) (Agalychnis litodryas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Agalychnis.
OX   NCBI_TaxID=317303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Skin secretion;
RX   PubMed=31671555; DOI=10.3390/biom9110667;
RA   Proano-Bolanos C., Blasco-Zuniga A., Almeida J.R., Wang L.,
RA   Llumiquinga M.A., Rivera M., Zhou M., Chen T., Shaw C.;
RT   "Unravelling the skin secretion peptides of the gliding leaf frog,
RT   Agalychnis spurrelli (Hylidae).";
RL   Biomolecules 9:1-20(2019).
CC   -!- FUNCTION: Induces relaxation of rat smooth muscle from tail artery and
CC       contraction of that from ileum, urinary bladder and uterus. Binds to
CC       both bradykinin receptor B1 (BDKRB1) and B2 (BDKRB2).
CC       {ECO:0000250|UniProtKB:L0PIN3}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31671555}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:31671555}.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Bradykinin-related peptide subfamily. {ECO:0000305}.
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DR   EMBL; MK766838; QFZ95564.1; -; mRNA.
DR   AlphaFoldDB; A0A5Q0MUM5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues;
KW   G-protein coupled receptor impairing toxin; Secreted; Signal; Toxin;
KW   Vasoactive; Vasodilator.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..51
FT                   /evidence="ECO:0000305|PubMed:31671555"
FT                   /id="PRO_0000449975"
FT   PEPTIDE         52..62
FT                   /note="[Ser6, Val10, Asp11]-phyllokinin"
FT                   /evidence="ECO:0000305|PubMed:31671555"
FT                   /id="PRO_0000449976"
FT   REGION          24..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..42
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   62 AA;  7298 MW;  36E9CDAF9DBFBF1E CRC64;
     MSFLKKSLLL VLFLGLVSFS ICEEEKRETE EEENEDDMDE ESEEKKRESP DRPPGFSPFR
     VD