ID   BRKP_PITRO              Reviewed;          11 AA.
AC   Q7LZ52;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   26-FEB-2020, entry version 41.
DE   RecName: Full=Phyllokinin;
DE   AltName: Full=Bradykinyl-isoleucyl-tyrosine O-sulfate;
OS   Pithecopus rohdei (Rohde's leaf frog) (Phyllomedusa rohdei).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=8394;
RN   [1]
RP   PROTEIN SEQUENCE, AND SULFATION AT TYR-11.
RC   TISSUE=Skin;
RX   PubMed=5970899; DOI=10.1111/j.1476-5381.1966.tb01859.x;
RA   Anastasi A., Bertaccini G., Erspamer V.;
RT   "Pharmacological data on phyllokinin (bradykinyl-isoleucyl-tyrosine O-
RT   sulphate) and bradykinyl-isoleucyl-tyrosine.";
RL   Br. J. Pharmacol. 27:479-485(1966).
CC   -!- FUNCTION: Induces relaxation of arterial smooth muscle, by targeting
CC       bradykinin receptors (BDKRB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC       {ECO:0000305}.
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DR   PIR; A61365; A61365.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing;
KW   G-protein coupled receptor impairing toxin; Secreted; Sulfation; Toxin;
KW   Vasoactive; Vasodilator.
FT   PEPTIDE         1..11
FT                   /note="Phyllokinin"
FT                   /id="PRO_0000043522"
FT   MOD_RES         11
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000269|PubMed:5970899"
SQ   SEQUENCE   11 AA;  1337 MW;  25051393D775B9C8 CRC64;
     RPPGFSPFRI Y