ID   BRK_AMICA               Reviewed;           9 AA.
AC   P84773; Q9PRJ4;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   26-FEB-2020, entry version 24.
DE   RecName: Full=[Trp5]-bradykinin;
OS   Amia calva (Bowfin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Amiiformes; Amiidae; Amia.
OX   NCBI_TaxID=7924;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Plasma {ECO:0000269|PubMed:7651903};
RX   PubMed=7651903; DOI=10.1016/0196-9781(94)00202-h;
RA   Conlon J.M., Platzack B., Marra L.E., Youson J.H., Olson K.R.;
RT   "Isolation and biological activity of [Trp5]bradykinin from the plasma of
RT   the phylogenetically ancient fish, the bowfin and the longnosed gar.";
RL   Peptides 16:485-489(1995).
CC   -!- FUNCTION: Induces smooth muscle dilation and contraction. Intra-
CC       arterial injection induces a significant decrease in ventral aortic
CC       blood pressure of between 5 and 10 minutes duration followed by a dose
CC       dependent increase in ventral aortic blood pressure of between 30 and
CC       60 minutes duration. May target bradykinin receptors (BDKRB).
CC       {ECO:0000269|PubMed:7651903}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7651903}.
CC   -!- TISSUE SPECIFICITY: Plasma. {ECO:0000269|PubMed:7651903}.
CC   -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0045776; P:negative regulation of blood pressure; IDA:UniProtKB.
DR   GO; GO:0045986; P:negative regulation of smooth muscle contraction; IDA:UniProtKB.
DR   GO; GO:0045777; P:positive regulation of blood pressure; IDA:UniProtKB.
DR   GO; GO:0045987; P:positive regulation of smooth muscle contraction; IDA:UniProtKB.
DR   GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; G-protein coupled receptor impairing toxin;
KW   Secreted; Toxin; Vasoactive; Vasoconstrictor; Vasodilator.
FT   PEPTIDE         1..9
FT                   /note="[Trp5]-bradykinin"
FT                   /id="PRO_0000223884"
SQ   SEQUENCE   9 AA;  1099 MW;  3393D775A3786777 CRC64;
     RPPGWSPFR