ID   BRK_LEPOS               Reviewed;           9 AA.
AC   P84774; Q9PRJ4;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   26-FEB-2020, entry version 25.
DE   RecName: Full=[Trp5]-bradykinin;
OS   Lepisosteus osseus (Long-nosed gar) (Esox osseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=34771;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Plasma {ECO:0000269|PubMed:7651903};
RX   PubMed=7651903; DOI=10.1016/0196-9781(94)00202-h;
RA   Conlon J.M., Platzack B., Marra L.E., Youson J.H., Olson K.R.;
RT   "Isolation and biological activity of [Trp5]bradykinin from the plasma of
RT   the phylogenetically ancient fish, the bowfin and the longnosed gar.";
RL   Peptides 16:485-489(1995).
CC   -!- FUNCTION: Induces smooth muscle dilation and contraction. May target
CC       bradykinin receptors (BDKRB). {ECO:0000269|PubMed:7651903}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7651903}.
CC   -!- TISSUE SPECIFICITY: Plasma. {ECO:0000269|PubMed:7651903}.
CC   -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0045986; P:negative regulation of smooth muscle contraction; ISS:UniProtKB.
DR   GO; GO:0045987; P:positive regulation of smooth muscle contraction; ISS:UniProtKB.
DR   GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; G-protein coupled receptor impairing toxin;
KW   Secreted; Toxin; Vasoactive; Vasoconstrictor; Vasodilator.
FT   PEPTIDE         1..9
FT                   /note="[Trp5]-bradykinin"
FT                   /id="PRO_0000223885"
SQ   SEQUENCE   9 AA;  1099 MW;  3393D775A3786777 CRC64;
     RPPGWSPFR