ID   BRK_POLMJ               Reviewed;          11 AA.
AC   P85873;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 21.
DE   RecName: Full=Wasp kinin PMM1 {ECO:0000303|PubMed:17559065};
DE   AltName: Full=Bradykinin-related peptide {ECO:0000305};
OS   Polistes major (Neotropical social wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Polistini; Polistes.
OX   NCBI_TaxID=91420;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   STRAIN=Subsp. major; TISSUE=Venom;
RX   PubMed=17559065; DOI=10.1002/psc.860;
RA   Cerovsky V., Pohl J., Yang Z., Alam N., Attygalle A.B.;
RT   "Identification of three novel peptides isolated from the venom of the
RT   neotropical social wasp Polistes major major.";
RL   J. Pept. Sci. 13:445-450(2007).
CC   -!- FUNCTION: Induces relaxation of arterial smooth muscle, by targeting
CC       bradykinin receptors (BDKRB) (By similarity). May cause hypotension.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17559065}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:17559065}.
CC   -!- MASS SPECTROMETRY: Mass=1359.3; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:17559065};
CC   -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR   InterPro; IPR009608; Bradykinin.
DR   Pfam; PF06753; Bradykinin; 1.
PE   1: Evidence at protein level;
KW   Bradykinin receptor impairing toxin; Direct protein sequencing;
KW   G-protein coupled receptor impairing toxin; Hypotensive agent; Secreted;
KW   Toxin; Vasoactive; Vasodilator.
FT   PEPTIDE         1..11
FT                   /note="Wasp kinin PMM1"
FT                   /evidence="ECO:0000269|PubMed:17559065"
FT                   /id="PRO_0000371796"
SQ   SEQUENCE   11 AA;  1359 MW;  33D415D6A9C86777 CRC64;
     KRRPPGFTPF R