ID   BRK_VESMA               Reviewed;          12 AA.
AC   Q7M3T3;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   29-SEP-2021, entry version 43.
DE   RecName: Full=Vespakinin-M {ECO:0000303|PubMed:1017116};
DE   AltName: Full=Bradykinin-related peptide {ECO:0000305};
OS   Vespa mandarinia (Asian giant hornet).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Vespinae; Vespa.
OX   NCBI_TaxID=7446;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND HYDROXYLATION AT PRO-4.
RC   TISSUE=Venom;
RX   PubMed=1017116; DOI=10.1248/cpb.24.2896;
RA   Kishimura H., Yasuhara T., Yoshida H., Nakajima T.;
RT   "Vespakinin-M, a novel bradykinin analogue containing hydroxyproline, in
RT   the venom of Vespa mandarinia Smith.";
RL   Chem. Pharm. Bull. 24:2896-2897(1976).
CC   -!- FUNCTION: Bradykinins are a potent but short-lived agent of arteriolar
CC       dilation and increased capillary permeability (By similarity). May
CC       target bradykinin receptors (BDKRB). May cause hypotension.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1017116}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:1017116}.
CC   -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC       {ECO:0000305}.
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DR   PIR; A61360; A61360.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Bradykinin receptor impairing toxin; Direct protein sequencing;
KW   G-protein coupled receptor impairing toxin; Hydroxylation;
KW   Hypotensive agent; Secreted; Toxin; Vasoactive; Vasodilator.
FT   PEPTIDE         1..12
FT                   /note="Vespakinin-M"
FT                   /evidence="ECO:0000269|PubMed:1017116"
FT                   /id="PRO_0000043517"
FT   MOD_RES         4
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:1017116"
SQ   SEQUENCE   12 AA;  1346 MW;  34F513C44C75B9C8 CRC64;
     GRPPGFSPFR ID