ID   BRK_VESMC               Reviewed;          17 AA.
AC   P57672;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Vespulakinin-1 {ECO:0000303|PubMed:1247511, ECO:0000303|PubMed:3679673};
DE   Contains:
DE     RecName: Full=Vespulakinin-2 {ECO:0000303|PubMed:1247511};
DE     AltName: Full=Bradykinin-related peptide {ECO:0000305};
OS   Vespula maculifrons (Eastern yellow jacket) (Wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Vespinae; Vespula.
OX   NCBI_TaxID=7453;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND GLYCOSYLATION AT THR-3 AND
RP   THR-4.
RC   TISSUE=Venom;
RX   PubMed=1247511; DOI=10.1021/bi00646a010;
RA   Yoshida H., Geller R.G., Pisano J.J.;
RT   "Vespulakinins: new carbohydrate-containing bradykinin derivatives.";
RL   Biochemistry 15:61-64(1976).
RN   [2]
RP   SYNTHESIS.
RX   PubMed=3679673; DOI=10.1111/j.1399-3011.1987.tb03332.x;
RA   Rocchi R., Biondi L., Filira F., Scolaro B.;
RT   "Synthesis, conformation, and biological activity of the carbohydrate-free
RT   vespulakinin 1.";
RL   Int. J. Pept. Protein Res. 30:240-256(1987).
CC   -!- FUNCTION: Induces smooth muscle contraction. May target bradykinin
CC       receptors (BDKRB). May cause hypotension.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1247511}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:1247511}.
CC   -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC       {ECO:0000305}.
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DR   PIR; A61339; A61339.
DR   AlphaFoldDB; P57672; -.
DR   iPTMnet; P57672; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Bradykinin receptor impairing toxin; Direct protein sequencing;
KW   G-protein coupled receptor impairing toxin; Glycoprotein;
KW   Hypotensive agent; Secreted; Toxin; Vasoactive; Vasodilator.
FT   PEPTIDE         1..17
FT                   /note="Vespulakinin-1"
FT                   /evidence="ECO:0000269|PubMed:1247511"
FT                   /id="PRO_0000003383"
FT   PEPTIDE         3..17
FT                   /note="Vespulakinin-2"
FT                   /evidence="ECO:0000269|PubMed:1247511"
FT                   /id="PRO_0000003384"
FT   CARBOHYD        3
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000269|PubMed:1247511"
FT   CARBOHYD        4
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000269|PubMed:1247511"
SQ   SEQUENCE   17 AA;  1960 MW;  58B2CBA864122323 CRC64;
     TATTRRRGRP PGFSPFR