ID   BRLA_ACRCH              Reviewed;         376 AA.
AC   A0A0A7HJC7;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   04-MAR-2015, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=C2H2 type master regulator of conidiophore development brlA {ECO:0000305};
GN   Name=brlA {ECO:0000303|PubMed:26283234};
OS   Acremonium chrysogenum (Cephalosporium acremonium).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreales incertae sedis; Acremonium.
OX   NCBI_TaxID=5044;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, FUNCTION, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=GMCC 3.3795;
RX   PubMed=26283234; DOI=10.1016/j.fgb.2015.08.003;
RA   Hu P., Wang Y., Zhou J., Pan Y., Liu G.;
RT   "AcstuA, which encodes an APSES transcription regulator, is involved in
RT   conidiation, cephalosporin biosynthesis and cell wall integrity of
RT   Acremonium chrysogenum.";
RL   Fungal Genet. Biol. 83:26-40(2015).
CC   -!- FUNCTION: BrlA, abaA and wetA are pivotal regulators of conidiophore
CC       development and conidium maturation (PubMed:26283234). They act
CC       individually and together to regulate their own expression and that of
CC       numerous other sporulation-specific genes (By similarity). Binds
CC       promoters of target genes at brlA response elements (BREs) containing
CC       the conserved sequence 5'-(C/A)(A/G)AGGG(G/A)-3' (By similarity).
CC       {ECO:0000250|UniProtKB:P22022, ECO:0000269|PubMed:26283234}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10069}.
CC   -!- INDUCTION: Expression is positively regulated by stuA through direct
CC       binding of stuA to the abaA promoter region (PubMed:26283234).
CC       {ECO:0000269|PubMed:26283234}.
CC   -!- DISRUPTION PHENOTYPE: Abolishes conidiation (PubMed:26283234).
CC       {ECO:0000269|PubMed:26283234}.
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DR   EMBL; KM207846; AIZ05821.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0A7HJC7; -.
DR   SMR; A0A0A7HJC7; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Conidiation; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Sporulation; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..376
FT                   /note="C2H2 type master regulator of conidiophore
FT                   development brlA"
FT                   /id="PRO_0000435950"
FT   ZN_FING         277..301
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         309..332
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          20..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..229
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   376 AA;  42535 MW;  1ECBB0A099766175 CRC64;
     MEDGFGMYSH SMSCPSTAST SFSSASSSAY DPFTPSSRRS TPNELSLDLD GSCSYAAHQH
     SLELTPPTTS MAKYFMGQTI KQEPEQMSFG SLPTTPMKKV DGGFAAEYDL IDMNMASHHS
     MGTITPSNSF GLHTISPETA MGPTSYMMTP TQSLSGSEIA ESSSSWSVTN ESPINFFQQP
     KDLSFHDMDS LDLDERHHHH HNHHQHHHAQ QSPMGQHFQL HSNTGASPNS MRVQRKMMLH
     EAQRKTSELQ RAQIRESRKR AGKPESGAVD VVRRAMCKCD YPGCNKAFRR NEHLKRHKQT
     FHGEGPNRFS CEFCGKDQFN RQDNLNNHRK LHARPNSRNR GVEFIPEAVP IIEHEERSRK
     RRAPPKSKAE KRDYDF