ID   BRLA_ASPOR              Reviewed;         421 AA.
AC   Q2UQZ5;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=C2H2 type master regulator of conidiophore development brlA {ECO:0000305};
GN   Name=brlA {ECO:0000303|PubMed:17213655}; ORFNames=AO090005001041;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
RN   [2]
RP   DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=17213655; DOI=10.1271/bbb.60405;
RA   Yamada O., Ikeda R., Ohkita Y., Hayashi R., Sakamoto K., Akita O.;
RT   "Gene silencing by RNA interference in the koji mold Aspergillus oryzae.";
RL   Biosci. Biotechnol. Biochem. 71:138-144(2007).
RN   [3]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION.
RX   PubMed=19850144; DOI=10.1016/j.fgb.2009.10.004;
RA   Ogawa M., Tokuoka M., Jin F.J., Takahashi T., Koyama Y.;
RT   "Genetic analysis of conidiation regulatory pathways in koji-mold
RT   Aspergillus oryzae.";
RL   Fungal Genet. Biol. 47:10-18(2010).
CC   -!- FUNCTION: BrlA, abaA and wetA are pivotal regulators of conidiophore
CC       development and conidium maturation (By similarity). They act
CC       individually and together to regulate their own expression and that of
CC       numerous other sporulation-specific genes (By similarity). Binds
CC       promoters of target genes at brlA response elements (BREs) containing
CC       the conserved sequence 5'-(C/A)(A/G)AGGG(G/A)-3' (By similarity).
CC       Required for conidiophores formation (PubMed:17213655). Controls
CC       expression of abaA (PubMed:19850144). {ECO:0000250|UniProtKB:P22022,
CC       ECO:0000269|PubMed:17213655, ECO:0000269|PubMed:19850144}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10069}.
CC   -!- INDUCTION: Expression is controlled by flbA, flbS and fluG
CC       (PubMed:19850144). {ECO:0000269|PubMed:19850144}.
CC   -!- DISRUPTION PHENOTYPE: Leads to delayed conidia development
CC       (PubMed:17213655, PubMed:19850144). {ECO:0000269|PubMed:17213655,
CC       ECO:0000269|PubMed:19850144}.
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DR   EMBL; AP007151; BAE56020.1; -; Genomic_DNA.
DR   RefSeq; XP_001818022.1; XM_001817970.2.
DR   AlphaFoldDB; Q2UQZ5; -.
DR   SMR; Q2UQZ5; -.
DR   STRING; 510516.Q2UQZ5; -.
DR   EnsemblFungi; BAE56020; BAE56020; AO090005001041.
DR   GeneID; 5989967; -.
DR   KEGG; aor:AO090005001041; -.
DR   VEuPathDB; FungiDB:AO090005001041; -.
DR   HOGENOM; CLU_655506_0_0_1; -.
DR   OMA; NPCLSRP; -.
DR   Proteomes; UP000006564; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; Conidiation; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Sporulation; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..421
FT                   /note="C2H2 type master regulator of conidiophore
FT                   development brlA"
FT                   /id="PRO_0000435943"
FT   ZN_FING         309..333
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         339..364
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          379..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   421 AA;  46826 MW;  D5D48A499086EE59 CRC64;
     MRTQNNLTVE VDCHSLGSNE CPSMTSSFSP MDSPTPTPTS IYSQGSLASP GWQDAGSYPG
     HAYERHTGAT PMRSAFRLAG MTSNENMGMS YGAMEAQERM PMPDFLSAYD DNVEHFWLPS
     DGPKTYETGT HSLPYPHTLP QCPPMVRSNY RPHAAYLPEA ATNPCLSRSI FHHAERVPQS
     MSMGNMMPWI PQATESIAPQ TIAPSQVGPV TPPPSYSEFP TSIQTFKTHS PTTPLRSCSI
     GTASGPDTPI SRLSGGAADY LEDFQQSPPF RDGLNRLQRQ PSRKMIRKQS SRQNMSLENL
     PSIIKQVQFK CKEPGCKGRF KRQEHLKRHM KSHSKEKPHV CWVPGCERAF SRSDNLNAHY
     TKTHSKRGGR NRYVATLDES SPDYDPDFRG QLTPDGLPIR GSTLDDPMPN SREYSVDGLD
     D