ID   BRLA_PENCA              Reviewed;         433 AA.
AC   Q58L83; A0A0G4PQS8;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 2.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=C2H2 type master regulator of conidiophore development brlA {ECO:0000305};
GN   Name=brlA {ECO:0000303|PubMed:18093806}; ORFNames=PCAMFM013_S028g000076;
OS   Penicillium camembertii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=5075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-341, AND INDUCTION.
RC   STRAIN=ENS1;
RX   PubMed=18093806; DOI=10.1016/j.resmic.2007.10.004;
RA   Boualem K., Wache Y., Garmyn D., Karbowiak T., Durand A., Gervais P.,
RA   Cavin J.F.;
RT   "Cloning and expression of genes involved in conidiation and surface
RT   properties of Penicillium camemberti grown in liquid and solid cultures.";
RL   Res. Microbiol. 159:110-117(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FM013;
RX   PubMed=24407037; DOI=10.1038/ncomms3876;
RA   Cheeseman K., Ropars J., Renault P., Dupont J., Gouzy J., Branca A.,
RA   Abraham A.L., Ceppi M., Conseiller E., Debuchy R., Malagnac F., Goarin A.,
RA   Silar P., Lacoste S., Sallet E., Bensimon A., Giraud T., Brygoo Y.;
RT   "Multiple recent horizontal transfers of a large genomic region in cheese
RT   making fungi.";
RL   Nat. Commun. 5:2876-2876(2014).
CC   -!- FUNCTION: BrlA, abaA and wetA are pivotal regulators of conidiophore
CC       development and conidium maturation (By similarity). They act
CC       individually and together to regulate their own expression and that of
CC       numerous other sporulation-specific genes (By similarity). Binds
CC       promoters of target genes at brlA response elements (BREs) containing
CC       the conserved sequence 5'-(C/A)(A/G)AGGG(G/A)-3' (By similarity).
CC       {ECO:0000250|UniProtKB:P22022}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10069}.
CC   -!- INDUCTION: A huge increase in expression is observed between the fourth
CC       and fifth day for solid and liquid cultures (PubMed:18093806).
CC       {ECO:0000269|PubMed:18093806}.
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DR   EMBL; AY940453; AAX37259.1; -; Genomic_DNA.
DR   EMBL; HG793161; CRL28523.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q58L83; -.
DR   SMR; Q58L83; -.
DR   EnsemblFungi; CRL28523; CRL28523; PCAMFM013_S028g000076.
DR   OrthoDB; 633411at2759; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; Conidiation; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Sporulation; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..433
FT                   /note="C2H2 type master regulator of conidiophore
FT                   development brlA"
FT                   /id="PRO_0000435949"
FT   ZN_FING         321..345
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         351..376
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          23..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          238..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          391..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   433 AA;  49070 MW;  31AFB8E2684C2457 CRC64;
     MRSHGQQISD RLTVEVDCHS LGPSECPSMT SSFSPLDSPT PTPTSLYSQG SMASPGWHEH
     PHYHHGVPME RRTSATPLRS AFRMADITSG DAMMNMPCGN MDRQDQMALP DYLPAYEENV
     DQLWIPQDMP KTYQEPQFPY HASMSQYNQM ARNYYHRPQQ AGYLPESASN PCLSRPIFTQ
     PTERMPNSAS MTNMLHWMPS HESLVPQTIT PAQVQPFPSG PVTPPSSSYS DFPTNIPTFK
     SHTPSTPHRS VSMGTPSGSD TPVSRMSGHN DYQEEFQLSP VYREGMMQRH RQPSRKSSKK
     QLLRSNLSLE NLPSIIKQVQ FKCKEPGCKG RFKRQEHLKR HMKSHSKEKP HVCWVPGCHR
     AFSRSDNLNA HYTKTHSKRG GRNRYVATLD ETSQDFDPDF RGQLTPDGRP IYGSKLEDSM
     PDCGELSVDG WDD