ID   BRLA_PENRF              Reviewed;         433 AA.
AC   W6QV39;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 2.
DT   03-AUG-2022, entry version 29.
DE   RecName: Full=C2H2 type master regulator of conidiophore development brlA {ECO:0000305};
GN   Name=brlA {ECO:0000303|PubMed:25811807}; ORFNames=PROQFM164_S08g000050;
OS   Penicillium roqueforti (strain FM164).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=1365484;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FM164;
RX   PubMed=24407037; DOI=10.1038/ncomms3876;
RA   Cheeseman K., Ropars J., Renault P., Dupont J., Gouzy J., Branca A.,
RA   Abraham A.L., Ceppi M., Conseiller E., Debuchy R., Malagnac F., Goarin A.,
RA   Silar P., Lacoste S., Sallet E., Bensimon A., Giraud T., Brygoo Y.;
RT   "Multiple recent horizontal transfers of a large genomic region in cheese
RT   making fungi.";
RL   Nat. Commun. 5:2876-2876(2014).
RN   [2]
RP   INDUCTION.
RX   PubMed=25811807; DOI=10.1371/journal.pone.0120740;
RA   Gil-Duran C., Rojas-Aedo J.F., Medina E., Vaca I., Garcia-Rico R.O.,
RA   Villagran S., Levican G., Chavez R.;
RT   "The pcz1 gene, which encodes a Zn(II)2Cys6 protein, is involved in the
RT   control of growth, conidiation, and conidial germination in the filamentous
RT   fungus Penicillium roqueforti.";
RL   PLoS ONE 10:E0120740-E0120740(2015).
CC   -!- FUNCTION: BrlA, abaA and wetA are pivotal regulators of conidiophore
CC       development and conidium maturation (By similarity). They act
CC       individually and together to regulate their own expression and that of
CC       numerous other sporulation-specific genes (By similarity). Binds
CC       promoters of target genes at brlA response elements (BREs) containing
CC       the conserved sequence 5'-(C/A)(A/G)AGGG(G/A)-3' (By similarity).
CC       {ECO:0000250|UniProtKB:P22022}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10069}.
CC   -!- INDUCTION: Expression is positively regulated by pcz1
CC       (PubMed:25811807). {ECO:0000269|PubMed:25811807}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CDM37999.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; HG792022; CDM37999.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; W6QV39; -.
DR   SMR; W6QV39; -.
DR   STRING; 1365484.W6QV39; -.
DR   EnsemblFungi; CDM37999; CDM37999; PROQFM164_S08g000050.
DR   OrthoDB; 633411at2759; -.
DR   Proteomes; UP000030686; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; Conidiation; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Sporulation; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..433
FT                   /note="C2H2 type master regulator of conidiophore
FT                   development brlA"
FT                   /id="PRO_0000435948"
FT   ZN_FING         321..345
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         351..376
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          23..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          238..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          391..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   433 AA;  49107 MW;  21FD0046C1F8273A CRC64;
     MRSHGQHISD RLTVEVDCHS LSSSECPSMT SGFSPLDSPT PTPTSLYSQG SMASPGWHDH
     PHYHHGVPME RRTSATPLRS AFRMADLTSS ETMMGMPCGT MDRQEQMPLP DYLPGYDENV
     DQLWIPQDMP KTYHEHQFPY QASMPQYNQM ARNYYHRPQQ AGYLPESASN PCLSRPIFTQ
     PTERMPNSAS MSNMLHWMPS HESLVPQTIT PAQVQPFPSG PVTPPSSSYS DFPTNIPTFK
     SHTPSTPHRS VSMGTPSGSD TPVSRMSGHN DYQEDFQLSP VYREGMMQRH RQPSRKSSKK
     QLLRSNLSLE NLPSIIKQVQ FKCKEPGCKG RFKRQEHLKR HMKSHSKEKP HVCWVPGCHR
     AFSRSDNLNA HYTKTHSKRG GRNRYVATLD ETSQDFDPDF RGQLTPDGRP IYGSKLEDTM
     PDCGELSVDG WDD