BRLA_PENRW
ID BRLA_PENRW Reviewed; 433 AA.
AC B6GVZ2;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=C2H2 type master regulator of conidiophore development brlA {ECO:0000305};
GN Name=brlA {ECO:0000303|PubMed:18364746}; ORFNames=Pc06g00470;
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
RN [2]
RP INDUCTION.
RX PubMed=18364746; DOI=10.1139/o07-148;
RA Garcia-Rico R.O., Fierro F., Martin J.F.;
RT "Heterotrimeric Galpha protein Pga1 of Penicillium chrysogenum controls
RT conidiation mainly by a cAMP-independent mechanism.";
RL Biochem. Cell Biol. 86:57-69(2008).
RN [3]
RP FUNCTION, AND INDUCTION.
RX PubMed=21148688; DOI=10.1128/aem.01557-10;
RA Sigl C., Haas H., Specht T., Pfaller K., Kuernsteiner H., Zadra I.;
RT "Among developmental regulators, StuA but not BrlA is essential for
RT penicillin V production in Penicillium chrysogenum.";
RL Appl. Environ. Microbiol. 77:972-982(2011).
CC -!- FUNCTION: BrlA, abaA and wetA are pivotal regulators of conidiophore
CC development and conidium maturation (By similarity). They act
CC individually and together to regulate their own expression and that of
CC numerous other sporulation-specific genes (By similarity). Binds
CC promoters of target genes at brlA response elements (BREs) containing
CC the conserved sequence 5'-(C/A)(A/G)AGGG(G/A)-3' (By similarity). Is
CC not required for penicillin V production (PubMed:21148688).
CC {ECO:0000250|UniProtKB:P22022, ECO:0000269|PubMed:21148688}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10069}.
CC -!- INDUCTION: Expression is regulated by the heterotrimeric G protein pga1
CC (PubMed:18364746). Expression is also positively regulated by stuA
CC (PubMed:21148688). {ECO:0000269|PubMed:18364746,
CC ECO:0000269|PubMed:21148688}.
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DR EMBL; AM920421; CAP79040.1; -; Genomic_DNA.
DR RefSeq; XP_002556662.1; XM_002556616.1.
DR AlphaFoldDB; B6GVZ2; -.
DR SMR; B6GVZ2; -.
DR STRING; 1108849.XP_002556662.1; -.
DR EnsemblFungi; CAP79040; CAP79040; PCH_Pc06g00470.
DR GeneID; 8315709; -.
DR KEGG; pcs:Pc06g00470; -.
DR VEuPathDB; FungiDB:PCH_Pc06g00470; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_655506_0_0_1; -.
DR OMA; NPCLSRP; -.
DR OrthoDB; 633411at2759; -.
DR BioCyc; PCHR:PC06G00470-MON; -.
DR Proteomes; UP000000724; Contig Pc00c06.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Activator; Conidiation; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Sporulation; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..433
FT /note="C2H2 type master regulator of conidiophore
FT development brlA"
FT /id="PRO_0000435945"
FT ZN_FING 321..345
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 351..376
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 23..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 433 AA; 48901 MW; 57592E39E0E35013 CRC64;
MRSHGQQISD RLTVEVDCHS LGPSECPSMT SSFSPLDSPT PTPTSLYSQG SMASPGWPEP
SHYHHGLPME RRTSATPLRS AFRMADLTSG EGMMNMPCGN MDRQEQMPLP DYLPGYDENV
DQLWIPQDMP KTYQEPQFPY QASMPQYNQM ARNYYHRPQQ AGYLPESASN PCLSRPIFTQ
STERMPNSAS MSNMLGWMPS HESLVPQTIT PAQVQPFPSG PVTPPSSSYS DFPANIPTFK
THTPSTPHRS VSMGTPSGSD TPVSRMSGHN DYQEDFQLSP VYREGMMQRH RQPSRKSSKK
QLLRSNLSLE NLPSIIKQVQ FKCKEPGCKG RFKRQEHLKR HMKSHSKEKP HVCWIPGCHR
AFSRSDNLNA HYTKTHSKRG GRNRYVATLD ETSQDFDPDF RGQLTPDGRP IYGSKLEDTM
PDCGELSVDG WDD
