ID   BRM1L_BOVIN             Reviewed;         323 AA.
AC   A4FV29;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Breast cancer metastasis-suppressor 1-like protein;
GN   Name=BRMS1L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the histone deacetylase (HDAC1)-dependent
CC       transcriptional repression activity. When overexpressed in lung cancer
CC       cell line that lacks p53/TP53 expression, inhibits cell growth (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Sin3/HDAC1 corepressor complex at least
CC       composed of BRMS1, BRMS1L and ING2/ING1L. Interacts with HDAC and SIN3A
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRMS1 family. {ECO:0000305}.
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DR   EMBL; BC123661; AAI23662.1; -; mRNA.
DR   RefSeq; NP_001076897.1; NM_001083428.1.
DR   AlphaFoldDB; A4FV29; -.
DR   SMR; A4FV29; -.
DR   IntAct; A4FV29; 1.
DR   STRING; 9913.ENSBTAP00000024481; -.
DR   PaxDb; A4FV29; -.
DR   PRIDE; A4FV29; -.
DR   Ensembl; ENSBTAT00000024481; ENSBTAP00000024481; ENSBTAG00000018400.
DR   GeneID; 514432; -.
DR   KEGG; bta:514432; -.
DR   CTD; 84312; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018400; -.
DR   eggNOG; KOG4466; Eukaryota.
DR   GeneTree; ENSGT00940000158921; -.
DR   HOGENOM; CLU_050862_2_0_1; -.
DR   InParanoid; A4FV29; -.
DR   OMA; ICIDRKD; -.
DR   OrthoDB; 1456563at2759; -.
DR   TreeFam; TF323740; -.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000018400; Expressed in occipital lobe and 104 other tissues.
DR   ExpressionAtlas; A4FV29; baseline and differential.
DR   GO; GO:0070822; C:Sin3-type complex; IBA:GO_Central.
DR   GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   InterPro; IPR013907; Sds3.
DR   PANTHER; PTHR21964; PTHR21964; 1.
DR   Pfam; PF08598; Sds3; 1.
DR   SMART; SM01401; Sds3; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Growth regulation; Isopeptide bond; Nucleus; Phosphoprotein;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Ubl conjugation.
FT   CHAIN           1..323
FT                   /note="Breast cancer metastasis-suppressor 1-like protein"
FT                   /id="PRO_0000305308"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          52..84
FT                   /evidence="ECO:0000255"
FT   COILED          149..180
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..50
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         197
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5PSV4"
FT   CROSSLNK        240
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q5PSV4"
FT   CROSSLNK        246
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q5PSV4"
SQ   SEQUENCE   323 AA;  37629 MW;  35908ACFD439A117 CRC64;
     MPVHSRGDKK ETNHHDEMEV DYAENEGSSS EDEDTESSSV SEDGDSSEMD DEDCERRRME
     CLDEMSNLEK QFTDLKDQLY KERLSQVDAK LQEVIAGKAP EYLEPLATLQ ENMQIRTKVA
     GIYRELCLES VKNKYECEIQ ASRQHCESEK LLLYDTVQSE LEEKIRRLEE DRHSIDITSE
     LWNDELQSRK KRKDPFSPDK KKPVVVSGPY IVYMLQDLDI LEDWTTIRKA MATLGPHRVK
     TEPPVKLEKH LHSARSEEGR LYYDGEWYIR GQTICIDKKD ECPTSAVITT INHDEVWFKR
     PDGSKSKLYI SQLQKGKYSI KHS