ID   BRM1L_CHICK             Reviewed;         323 AA.
AC   Q5ZLL9;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Breast cancer metastasis-suppressor 1-like protein;
GN   Name=BRMS1L; ORFNames=RCJMB04_5j5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Involved in the histone deacetylase (HDAC1)-dependent
CC       transcriptional repression activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRMS1 family. {ECO:0000305}.
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DR   EMBL; AJ719715; CAG31374.1; -; mRNA.
DR   RefSeq; NP_001007936.1; NM_001007935.1.
DR   AlphaFoldDB; Q5ZLL9; -.
DR   SMR; Q5ZLL9; -.
DR   STRING; 9031.ENSGALP00000016398; -.
DR   PaxDb; Q5ZLL9; -.
DR   GeneID; 423328; -.
DR   KEGG; gga:423328; -.
DR   CTD; 84312; -.
DR   VEuPathDB; HostDB:geneid_423328; -.
DR   eggNOG; KOG4466; Eukaryota.
DR   HOGENOM; CLU_050862_2_0_1; -.
DR   InParanoid; Q5ZLL9; -.
DR   OrthoDB; 1456563at2759; -.
DR   PhylomeDB; Q5ZLL9; -.
DR   PRO; PR:Q5ZLL9; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0070822; C:Sin3-type complex; IBA:GO_Central.
DR   GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR013907; Sds3.
DR   PANTHER; PTHR21964; PTHR21964; 1.
DR   Pfam; PF08598; Sds3; 1.
DR   SMART; SM01401; Sds3; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..323
FT                   /note="Breast cancer metastasis-suppressor 1-like protein"
FT                   /id="PRO_0000305311"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          50..82
FT                   /evidence="ECO:0000255"
FT   COILED          147..178
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..48
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   323 AA;  37766 MW;  3E209C8FB27D9B52 CRC64;
     MPVHSREKKE NNHDEMEVDY GENEGSTSEE EETESSSVSE EGDSSEMDDE DCERRRMECL
     DEMSNLEKQF TDLKDQLYKE RLSQVDAKLQ EVIAGKAPEY LEPLAALQEN MQIRTKVAGI
     YRELCLESVK NKYECEIQAS RQHCESEKLL LYDTVQSELE EKIRRLEEDR HSIDITSELW
     NDELQSRKKR KDPFSPDKKK PVVVSGPYIV YMLQDLDILE DWTTIRKAMA TLGPHRVKPE
     PPVKLEKHLH SARSEEGRLY YDGEWYGRGQ TIYIDKKDEC PTSAIITTIN HDEVWFKRPD
     GSKSKLYISQ LQKGKYSIKH NHN