ID   BRM1L_XENTR             Reviewed;         322 AA.
AC   A4II71;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Breast cancer metastasis-suppressor 1-like protein;
GN   Name=brms1l;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the histone deacetylase (HDAC1)-dependent
CC       transcriptional repression activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRMS1 family. {ECO:0000305}.
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DR   EMBL; BC135888; AAI35889.1; -; mRNA.
DR   RefSeq; NP_001096366.1; NM_001102896.2.
DR   AlphaFoldDB; A4II71; -.
DR   SMR; A4II71; -.
DR   STRING; 8364.ENSXETP00000058775; -.
DR   PaxDb; A4II71; -.
DR   GeneID; 100124958; -.
DR   KEGG; xtr:100124958; -.
DR   CTD; 84312; -.
DR   Xenbase; XB-GENE-1002972; brms1l.
DR   eggNOG; KOG4466; Eukaryota.
DR   InParanoid; A4II71; -.
DR   OrthoDB; 1456563at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000002912; Expressed in egg cell and 13 other tissues.
DR   GO; GO:0070822; C:Sin3-type complex; IBA:GO_Central.
DR   GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR013907; Sds3.
DR   PANTHER; PTHR21964; PTHR21964; 1.
DR   Pfam; PF08598; Sds3; 1.
DR   SMART; SM01401; Sds3; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..322
FT                   /note="Breast cancer metastasis-suppressor 1-like protein"
FT                   /id="PRO_0000305314"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          50..82
FT                   /evidence="ECO:0000255"
FT   COILED          147..178
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..48
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   322 AA;  37541 MW;  D085B03DBE877C61 CRC64;
     MPVHSREKKE SNHNDMEVDY PENEGTSSEE DDSDSSSGSE EGDSSEMDDE DCERRRMECL
     DEMSNLEKQF TDLKDQLYKE RLSQVDAKLQ EVIAGKAPEY LEPLANLQEN MQIRTKVAGI
     YRELCLESVK NKHDCEIQAA RQHCESEKLL LYDTVQSELE EKIRRLEEDR HSIDITSELW
     NDELQSRRKR KDPFSPDKKK KPVVVSGPYI VYMLQDLDIL EDWTTIRKAM ASFGPHRVKP
     EVTVKMEKHQ HSARSEEGRL HYDGEWYGRG QTICIDKKDE FPTSAVITTI NSDEVWFKRQ
     DGSKSKLYIS QLQKGKYSIK HI