BRN1_ARATH
ID BRN1_ARATH Reviewed; 305 AA.
AC Q9C878;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Protein BEARSKIN1;
DE AltName: Full=NAC domain-containing protein 15;
DE Short=ANAC015;
GN Name=BRN1; Synonyms=NAC015; OrderedLocusNames=At1g33280; ORFNames=T16O9.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15029955; DOI=10.1093/dnares/10.6.239;
RA Ooka H., Satoh K., Doi K., Nagata T., Otomo Y., Murakami K., Matsubara K.,
RA Osato N., Kawai J., Carninci P., Hayashizaki Y., Suzuki K., Kojima K.,
RA Takahara Y., Yamamoto K., Kikuchi S.;
RT "Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis
RT thaliana.";
RL DNA Res. 10:239-247(2003).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=20197506; DOI=10.1105/tpc.109.072272;
RA Bennett T., van den Toorn A., Sanchez-Perez G.F., Campilho A.,
RA Willemsen V., Snel B., Scheres B.;
RT "SOMBRERO, BEARSKIN1, and BEARSKIN2 regulate root cap maturation in
RT Arabidopsis.";
RL Plant Cell 22:640-654(2010).
CC -!- FUNCTION: Transcription activator. Together with SMB and BRN2,
CC regulates cellular maturation of root cap. Promotes the expression of
CC genes involved in secondary cell walls (SCW) biosynthesis.
CC {ECO:0000269|PubMed:20197506}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the root cap, in both columella (COL)
CC and COL-adjoining lateral root cap (LRC) cells. Also present at low
CC levels expression in the tips of cotyledons and the cotyledon
CC vasculature, as weel as in vasculature of the first pair of true leaves
CC and at the hydathodes. {ECO:0000269|PubMed:20197506}.
CC -!- DEVELOPMENTAL STAGE: Detectable in lateral root development when they
CC reach 1 mm long. {ECO:0000269|PubMed:20197506}.
CC -!- DOMAIN: The NAC domain includes a DNA-binding domain and a dimerization
CC domain.
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DR EMBL; AC027035; AAG51291.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31580.1; -; Genomic_DNA.
DR PIR; F86456; F86456.
DR RefSeq; NP_174598.1; NM_103057.4.
DR AlphaFoldDB; Q9C878; -.
DR SMR; Q9C878; -.
DR BioGRID; 25457; 2.
DR IntAct; Q9C878; 2.
DR STRING; 3702.AT1G33280.1; -.
DR PaxDb; Q9C878; -.
DR PRIDE; Q9C878; -.
DR ProteomicsDB; 240702; -.
DR EnsemblPlants; AT1G33280.1; AT1G33280.1; AT1G33280.
DR GeneID; 840223; -.
DR Gramene; AT1G33280.1; AT1G33280.1; AT1G33280.
DR KEGG; ath:AT1G33280; -.
DR Araport; AT1G33280; -.
DR TAIR; locus:2196641; AT1G33280.
DR eggNOG; ENOG502R8AM; Eukaryota.
DR HOGENOM; CLU_035664_1_3_1; -.
DR InParanoid; Q9C878; -.
DR OMA; SYEKFEM; -.
DR OrthoDB; 1138596at2759; -.
DR PhylomeDB; Q9C878; -.
DR PRO; PR:Q9C878; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C878; baseline and differential.
DR Genevisible; Q9C878; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:TAIR.
DR GO; GO:0009834; P:plant-type secondary cell wall biogenesis; IMP:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IEP:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0048829; P:root cap development; IMP:UniProtKB.
DR Gene3D; 2.170.150.80; -; 1.
DR InterPro; IPR033519; BRN1/BRN2.
DR InterPro; IPR003441; NAC-dom.
DR InterPro; IPR036093; NAC_dom_sf.
DR PANTHER; PTHR31989:SF368; PTHR31989:SF368; 1.
DR Pfam; PF02365; NAM; 1.
DR SUPFAM; SSF101941; SSF101941; 1.
DR PROSITE; PS51005; NAC; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..305
FT /note="Protein BEARSKIN1"
FT /id="PRO_0000394191"
FT DOMAIN 8..156
FT /note="NAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
FT DNA_BIND 108..162
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00353"
SQ SEQUENCE 305 AA; 35253 MW; 1AC7C6C09812A98E CRC64;
MSSSNGGVPP GFRFHPTDEE LLHYYLKKKI SYEKFEMEVI KEVDLNKIEP WDLQDRCKIG
STPQNEWYFF SHKDRKYPTG SRTNRATHSG FWKATGRDKC IRNSYKKIGM RKTLVFYKGR
APHGQKTDWI MHEYRIEDTE DDPCEDGWVV CRVFKKKNLF KVGNDVGSNI SNNRLEARSF
IRRESPYQGI SMFELNKPEE ISVHQYPQPP MFQPHHKPLS IGYDYSLALL PRESEYQQAC
QPSGVEVGTC KAVSEWGIVN CNMVSHEDSS RAMRFEDDGN NTSSTVQPPS NLLSLRGENG
FLGLF
