ID   BRN3_CHICK              Reviewed;         341 AA.
AC   Q91998;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Brain-specific homeobox/POU domain protein 3;
DE            Short=Brain-3;
DE            Short=Brn-3;
GN   Name=BRN3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Spinal ganglion;
RX   PubMed=9205808; DOI=10.1016/s0165-3806(97)00038-2;
RA   Lindeberg J.K., Klint P., Williams R., Ebendal T.;
RT   "Identification of a chicken homologue in the Brn-3 subfamily of POU-
RT   transcription factors.";
RL   Brain Res. Dev. Brain Res. 100:169-182(1997).
CC   -!- FUNCTION: May play a role in specifying terminally differentiated
CC       neuronal phenotypes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-4
CC       subfamily. {ECO:0000305}.
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DR   EMBL; X91998; CAA63049.1; -; mRNA.
DR   EMBL; X91997; CAA63048.1; -; Genomic_DNA.
DR   RefSeq; NP_990090.1; NM_204759.1.
DR   AlphaFoldDB; Q91998; -.
DR   SMR; Q91998; -.
DR   STRING; 9031.ENSGALP00000041494; -.
DR   PaxDb; Q91998; -.
DR   Ensembl; ENSGALT00000061255; ENSGALP00000055381; ENSGALG00000034567.
DR   GeneID; 395521; -.
DR   KEGG; gga:395521; -.
DR   CTD; 395521; -.
DR   VEuPathDB; HostDB:geneid_395521; -.
DR   eggNOG; KOG1168; Eukaryota.
DR   GeneTree; ENSGT00940000165106; -.
DR   HOGENOM; CLU_013065_0_0_1; -.
DR   InParanoid; Q91998; -.
DR   OMA; PKYTHLH; -.
DR   OrthoDB; 929123at2759; -.
DR   PhylomeDB; Q91998; -.
DR   PRO; PR:Q91998; -.
DR   Proteomes; UP000000539; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..341
FT                   /note="Brain-specific homeobox/POU domain protein 3"
FT                   /id="PRO_0000100744"
FT   DOMAIN          182..259
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT   DNA_BIND        277..336
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   MOTIF           55..65
FT                   /note="POU-IV box"
SQ   SEQUENCE   341 AA;  37773 MW;  6A4C741C88C07D5F CRC64;
     MMSMNSKQAF SMHPILHEPK YPHLHTSSEA IRRACLPAPQ IQGNIFAGFD ETLLRGAEAL
     AAVDIVSQKT HPFKPDATYH TMSSVSCTPT SSSVHLHHPS VLTTHHPHHH HHQPAQGLEG
     ELLDHLNSAL PLGGVPGPDV GSTPSHPHSH MSAINHMAHH SQPMNMSHPH GLASHAVISG
     PETETDPREL ESFAERFKQR RIKLGVTQAD VGSALANLKI PGVGCLSQST ICRFESLTLS
     HNNMVALKPI LEAWLEEAER AQREKMTKPE IYTGGDKKRK RTSIAAPEKR SLEAYFAVQP
     RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRMKFSAT Y