ID   BRNP1_BOVIN             Reviewed;         761 AA.
AC   Q5E9L2;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=BMP/retinoic acid-inducible neural-specific protein 1;
DE   AltName: Full=Deleted in bladder cancer protein 1 homolog;
DE   Flags: Precursor;
GN   Name=BRINP1; Synonyms=DBC1, FAM5A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Inhibits cell proliferation by negative regulation of the
CC       G1/S transition. Mediates cell death which is not of the classical
CC       apoptotic type and regulates expression of components of the
CC       plasminogen pathway (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRINP family. {ECO:0000305}.
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DR   EMBL; BT020908; AAX08925.1; -; mRNA.
DR   RefSeq; NP_001015669.1; NM_001015669.1.
DR   AlphaFoldDB; Q5E9L2; -.
DR   STRING; 9913.ENSBTAP00000021192; -.
DR   PaxDb; Q5E9L2; -.
DR   GeneID; 538990; -.
DR   KEGG; bta:538990; -.
DR   CTD; 1620; -.
DR   eggNOG; ENOG502QT9H; Eukaryota.
DR   InParanoid; Q5E9L2; -.
DR   OrthoDB; 157712at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:AgBase.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0008219; P:cell death; ISS:AgBase.
DR   GO; GO:0045786; P:negative regulation of cell cycle; ISS:AgBase.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; IEA:InterPro.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:InterPro.
DR   InterPro; IPR033237; BRINP.
DR   InterPro; IPR020864; MACPF.
DR   PANTHER; PTHR15564; PTHR15564; 1.
DR   Pfam; PF19052; BRINP; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00457; MACPF; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Glycoprotein; Growth arrest; Reference proteome;
KW   Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..761
FT                   /note="BMP/retinoic acid-inducible neural-specific protein
FT                   1"
FT                   /id="PRO_0000045765"
FT   DOMAIN          68..251
FT                   /note="MACPF"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        433
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        443
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        553
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        599
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        631
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        677
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   761 AA;  88746 MW;  61E9D2F2302C2569 CRC64;
     MNWRFVELLY FLFVWGRISV QPSHQEPAAT DQHVSKEFDW LISDRGPFHH SRSYLSFVER
     HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE FQRSIRLLGR RPTTQQFIDT
     VIKKYGTHLL ISATLGGEEA LTMYMDKSRL DRKSGNATQS VEALHQLASS YFVDRDGTMR
     RLHEIQISTG AIKVTETRTG PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE
     KFVQSALSYI MCNGEGEYVC QNSQCRCQCA EEFPQCNCPI TDIQIMEYTL ASMAKSWAEA
     YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQN RYKLLQSAME AQRQKIQRTA
     RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN GFWGTFLESQ RSCVCHGSTT
     LCQRPIPCII GGNNSCAMCS LANISLCGSC NKGYKLYRGR CEPQNVDSER SEQFISFETD
     LDFQDLELKY LLQKMDSRLY VHTTFISNEI RLDTFFDPRW RKRLSLTLKS NKNRMDFIHM
     VIGMSMRICQ MRNSSLDPMF FVYINPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW
     TLLLGNRWKT FFETVHIYLR SRTRLPTLLR NETGQGPVDL SDPSKRQFYI KISDVQVFGY
     SLRFNADLLR SAVQQVNQSY TQGGQFYSSS SVMLLLLDIR DRINRLAPPV APGKPQLDLF
     SCMLKHRLKL TNSEIIRVNH ALDLYNTEIL KQSDQMTAKL C