ID   BRNP1_CHICK             Reviewed;         761 AA.
AC   Q7ZZR3;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=BMP/retinoic acid-inducible neural-specific protein 1;
DE   AltName: Full=Deleted in bladder cancer protein 1 homolog;
DE   Flags: Precursor;
GN   Name=BRINP1; Synonyms=BRINP, DBC1, FAM5A;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Stubbusch J.;
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits cell proliferation by negative regulation of the
CC       G1/S transition. Has been shown to mediate cell death which is not of
CC       the classical apoptotic type and to regulate expression of components
CC       of the plasminogen pathway (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRINP family. {ECO:0000305}.
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DR   EMBL; AJ558161; CAD90040.1; -; mRNA.
DR   RefSeq; NP_989780.1; NM_204449.1.
DR   AlphaFoldDB; Q7ZZR3; -.
DR   STRING; 9031.ENSGALP00000011314; -.
DR   PaxDb; Q7ZZR3; -.
DR   Ensembl; ENSGALT00000011328; ENSGALP00000011314; ENSGALG00000006997.
DR   GeneID; 395098; -.
DR   KEGG; gga:395098; -.
DR   CTD; 1620; -.
DR   VEuPathDB; HostDB:geneid_395098; -.
DR   eggNOG; ENOG502QT9H; Eukaryota.
DR   GeneTree; ENSGT00940000158084; -.
DR   HOGENOM; CLU_018347_0_0_1; -.
DR   InParanoid; Q7ZZR3; -.
DR   OMA; MSESWAS; -.
DR   OrthoDB; 157712at2759; -.
DR   PhylomeDB; Q7ZZR3; -.
DR   TreeFam; TF331600; -.
DR   PRO; PR:Q7ZZR3; -.
DR   Proteomes; UP000000539; Chromosome 17.
DR   Bgee; ENSGALG00000006997; Expressed in cerebellum and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0008219; P:cell death; ISS:UniProtKB.
DR   GO; GO:0071300; P:cellular response to retinoic acid; IBA:GO_Central.
DR   GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; IBA:GO_Central.
DR   InterPro; IPR033237; BRINP.
DR   InterPro; IPR020864; MACPF.
DR   PANTHER; PTHR15564; PTHR15564; 1.
DR   Pfam; PF19052; BRINP; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00457; MACPF; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Glycoprotein; Growth arrest; Reference proteome;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..761
FT                   /note="BMP/retinoic acid-inducible neural-specific protein
FT                   1"
FT                   /id="PRO_0000045769"
FT   DOMAIN          68..251
FT                   /note="MACPF"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        433
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        443
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        553
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        599
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        631
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        677
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   761 AA;  88793 MW;  8D0B03F5910D1473 CRC64;
     MNWRLVEFLY LLFIWDHILV QPSHQDPAAT NQHVSKEFDW LISDRGPFHH SRSYLSFVER
     HRQGFTTRYK IYREFARWKV RNTAIERRDL LHNPLPLMPE FQRSIRLLGR RPTTQQFIDT
     IIKKYGTHIL ISATLGGEEA LTMYMDKSRL DRKSGNATQS VEALHQLASS YFVDRDGTMR
     RLHEIQISTG AIKVTETRTG PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE
     KFVQSALSYI MCNGEGEYIC RNSQCGCQCA EEFPQCNCPI TDIQIMEYTL ANMAKTWTEA
     YKDLENSDEF KSFMKRLPSN HFLTIASIHQ HWGNDWDLQN RYKLLQSSLE AQRQKIQRTA
     RKLFGLSVRC RHNPNHQLPR ERTIQEWLTR VQSLLYCNEN GFWGTFLESQ RSCVCHGGTS
     LCQRPIPCII GGNNSCAMCS LANISLCGSC NKGYKLYRGR CEPQNVDSER SEQFISFETD
     LDFQDLELKY LLQKMDSRLY VHTTFISNEI RLDTFFDPRW RKRMSLTLKS NKNRMDFIHM
     VIGISMRICQ MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EYGYPRWEKI RLQNSQCYNW
     TLLLGNRWKT FFETVHIYLR SRTRLPSLLR NETGQGPVDL SDPSKRQFYI KISDVQVYGY
     SLRFNADLLR SAVQQVNQSY TQGGQFYSSS SVMLLLLDIR DRINRLAPPV APGKPQLDLF
     SCMLKHRLKL TNSEIIRVNH ALDLYNTEIL KQSDQMTAKL C