BRNP1_MOUSE
ID BRNP1_MOUSE Reviewed; 760 AA.
AC Q920P3; Q80ZL2; Q812F0; Q8C1C9; Q920P4; Q9QXL0;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=BMP/retinoic acid-inducible neural-specific protein 1;
DE AltName: Full=Deleted in bladder cancer protein 1 homolog;
DE Flags: Precursor;
GN Name=Brinp1; Synonyms=Brinp, Dbc1, Dbccr1, Fam5a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RC TISSUE=Brain, and Embryonic stem cell;
RX PubMed=15193423; DOI=10.1016/j.molbrainres.2004.04.001;
RA Kawano H., Nakatani T., Mori T., Ueno S., Fukaya M., Abe A., Kobayashi M.,
RA Toda F., Watanabe M., Matsuoka I.;
RT "Identification and characterization of novel developmentally regulated
RT neural-specific proteins, BRINP family.";
RL Brain Res. Mol. Brain Res. 125:60-75(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Ochal L.K., Sowden M.P., Messing E.M., Wheeless L.L., Reeder J.E.;
RT "Mouse DBCCR1 cDNA.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [7]
RP FUNCTION, INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=20025061; DOI=10.1002/jnr.22315;
RA Terashima M., Kobayashi M., Motomiya M., Inoue N., Yoshida T., Okano H.,
RA Iwasaki N., Minami A., Matsuoka I.;
RT "Analysis of the expression and function of BRINP family genes during
RT neuronal differentiation in mouse embryonic stem cell-derived neural stem
RT cells.";
RL J. Neurosci. Res. 88:1387-1393(2010).
CC -!- FUNCTION: Inhibits cell proliferation by negative regulation of the
CC G1/S transition. Mediates cell death which is not of the classical
CC apoptotic type and regulates expression of components of the
CC plasminogen pathway. {ECO:0000269|PubMed:20025061}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q920P3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q920P3-2; Sequence=VSP_017024, VSP_017025;
CC -!- TISSUE SPECIFICITY: Expressed in brain. Weakly expressed in embryonic
CC stem (ES) cells and in ES-derived neural stem cells (NSCs).
CC {ECO:0000269|PubMed:15193423, ECO:0000269|PubMed:20025061}.
CC -!- DEVELOPMENTAL STAGE: Expressed from 9.5 dpc.
CC {ECO:0000269|PubMed:15193423}.
CC -!- INDUCTION: Up-regulated upon differentiation into neuronal cells in the
CC presence of retinoic acid and BDNF. Up-regulated upon differentiation
CC into astroglial cells. {ECO:0000269|PubMed:20025061}.
CC -!- SIMILARITY: Belongs to the BRINP family. {ECO:0000305}.
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DR EMBL; AB060587; BAB70600.1; -; Genomic_DNA.
DR EMBL; AB060589; BAB70601.1; -; mRNA.
DR EMBL; AB088118; BAC55204.1; -; Genomic_DNA.
DR EMBL; AF202896; AAF17579.1; -; mRNA.
DR EMBL; AK028321; BAC25879.1; -; mRNA.
DR EMBL; AK045420; BAC32355.1; -; mRNA.
DR EMBL; BX088573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX649413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC048789; AAH48789.1; -; mRNA.
DR EMBL; BC079630; AAH79630.1; -; mRNA.
DR CCDS; CCDS18272.1; -. [Q920P3-1]
DR RefSeq; NP_064351.2; NM_019967.2. [Q920P3-1]
DR AlphaFoldDB; Q920P3; -.
DR BioGRID; 208138; 3.
DR STRING; 10090.ENSMUSP00000030036; -.
DR GlyConnect; 2157; 5 N-Linked glycans (2 sites).
DR GlyGen; Q920P3; 7 sites, 5 N-linked glycans (2 sites).
DR PhosphoSitePlus; Q920P3; -.
DR SwissPalm; Q920P3; -.
DR MaxQB; Q920P3; -.
DR PaxDb; Q920P3; -.
DR PeptideAtlas; Q920P3; -.
DR PRIDE; Q920P3; -.
DR ProteomicsDB; 273704; -. [Q920P3-1]
DR ProteomicsDB; 273705; -. [Q920P3-2]
DR Antibodypedia; 30047; 217 antibodies from 25 providers.
DR DNASU; 56710; -.
DR Ensembl; ENSMUST00000030036; ENSMUSP00000030036; ENSMUSG00000028351. [Q920P3-1]
DR GeneID; 56710; -.
DR KEGG; mmu:56710; -.
DR UCSC; uc008thw.1; mouse. [Q920P3-1]
DR UCSC; uc008thx.1; mouse. [Q920P3-2]
DR CTD; 1620; -.
DR MGI; MGI:1928478; Brinp1.
DR VEuPathDB; HostDB:ENSMUSG00000028351; -.
DR eggNOG; ENOG502QT9H; Eukaryota.
DR GeneTree; ENSGT00940000158084; -.
DR HOGENOM; CLU_018347_0_0_1; -.
DR InParanoid; Q920P3; -.
DR OMA; MSESWAS; -.
DR OrthoDB; 157712at2759; -.
DR PhylomeDB; Q920P3; -.
DR TreeFam; TF331600; -.
DR BioGRID-ORCS; 56710; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Brinp1; mouse.
DR PRO; PR:Q920P3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q920P3; protein.
DR Bgee; ENSMUSG00000028351; Expressed in visual cortex and 138 other tissues.
DR Genevisible; Q920P3; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0001662; P:behavioral fear response; IMP:MGI.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0008219; P:cell death; ISS:UniProtKB.
DR GO; GO:0071300; P:cellular response to retinoic acid; IDA:UniProtKB.
DR GO; GO:0035640; P:exploration behavior; IMP:MGI.
DR GO; GO:0042711; P:maternal behavior; IMP:MGI.
DR GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; IDA:UniProtKB.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IMP:MGI.
DR GO; GO:0022008; P:neurogenesis; IMP:MGI.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:UniProtKB.
DR GO; GO:0007614; P:short-term memory; IMP:MGI.
DR GO; GO:0035176; P:social behavior; IMP:MGI.
DR GO; GO:0071625; P:vocalization behavior; IMP:MGI.
DR InterPro; IPR033237; BRINP.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR15564; PTHR15564; 1.
DR Pfam; PF19052; BRINP; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cytoplasm; Glycoprotein; Growth arrest;
KW Reference proteome; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..760
FT /note="BMP/retinoic acid-inducible neural-specific protein
FT 1"
FT /id="PRO_0000045767"
FT DOMAIN 68..251
FT /note="MACPF"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 433
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 443
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 553
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 599
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 630
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 676
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 308..320
FT /note="DEFKSFMKRLPSN -> GTQTTTVNASGQT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_017024"
FT VAR_SEQ 321..760
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_017025"
FT CONFLICT 62
FT /note="R -> Q (in Ref. 3; BAC25879)"
FT /evidence="ECO:0000305"
FT CONFLICT 157..158
FT /note="AT -> VP (in Ref. 2; AAF17579)"
FT /evidence="ECO:0000305"
FT CONFLICT 550..551
FT /note="QM -> FQR (in Ref. 2; AAF17579)"
FT /evidence="ECO:0000305"
FT CONFLICT 608
FT /note="W -> V (in Ref. 2; AAF17579)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 760 AA; 88641 MW; 746E954368F1E49A CRC64;
MNWRFVELLY FLFVWGRISV QPSRQEPAGT DQHVSKEFDW LISDRGPFHH SRSYLSFVER
HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE FQRSIRLLGR RPTTQQFIDT
IIKKYGTHLL ISATLGGEEA LTMYMDKSRL DRKSGNATQS VEALHQLASS YFVDRDGTMR
RLHEIQISTG AIKVTETRTG PLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE
KFVQSALSYI MCNGEGEYVC QNSQCRCQCA EEFPQCNCPI TDIQIMEFTL ANMAKAWTEA
YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQS RYKLLQSATE AQRQKIQRTA
RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN GFWGTFLESQ RSCVCHGSTT
LCQRPIPCII GGNNSCAMCS LANISLCGSC NKGYKLYRGR CEPQNVDSER SEQFISFETD
LDFQDLELKY LLQKMDSRLY VHTTFISNEI RLDTFFDPRW RKRMSLTLKS NKNRMDFIHM
VIGMSMRICQ MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW
TLLLGNRWKT FFETVHIYLR SRTRLPTLRN ETGQGPVDLS DPSKRQFYIK ISDVQVFGYS
LRFNADLLRS AVQQVNQSYT QGGQFYSSSS VMLLMLDIRD RINRLAPPVA PGKPQLDLFS
CMLKHRLKLT NSEIIRVNHA LDLYNTEILK QSDQMTAKLC
