ID   BRNP1_RAT               Reviewed;         760 AA.
AC   Q925T8;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=BMP/retinoic acid-inducible neural-specific protein 1;
DE   AltName: Full=Deleted in bladder cancer protein 1 homolog;
DE   Flags: Precursor;
GN   Name=Brinp1; Synonyms=Brinp, Dbc1, Dbccr1, Fam5a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=15193423; DOI=10.1016/j.molbrainres.2004.04.001;
RA   Kawano H., Nakatani T., Mori T., Ueno S., Fukaya M., Abe A., Kobayashi M.,
RA   Toda F., Watanabe M., Matsuoka I.;
RT   "Identification and characterization of novel developmentally regulated
RT   neural-specific proteins, BRINP family.";
RL   Brain Res. Mol. Brain Res. 125:60-75(2004).
CC   -!- FUNCTION: Inhibits cell proliferation by negative regulation of the
CC       G1/S transition. Mediates cell death which is not of the classical
CC       apoptotic type and regulates expression of components of the
CC       plasminogen pathway (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRINP family. {ECO:0000305}.
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DR   EMBL; AB051356; BAB55642.1; -; mRNA.
DR   RefSeq; NP_536730.1; NM_080482.2.
DR   AlphaFoldDB; Q925T8; -.
DR   STRING; 10116.ENSRNOP00000007578; -.
DR   GlyGen; Q925T8; 7 sites.
DR   PhosphoSitePlus; Q925T8; -.
DR   PaxDb; Q925T8; -.
DR   GeneID; 140610; -.
DR   KEGG; rno:140610; -.
DR   UCSC; RGD:708519; rat.
DR   CTD; 1620; -.
DR   RGD; 708519; Brinp1.
DR   eggNOG; ENOG502QT9H; Eukaryota.
DR   InParanoid; Q925T8; -.
DR   OrthoDB; 157712at2759; -.
DR   PhylomeDB; Q925T8; -.
DR   PRO; PR:Q925T8; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR   GO; GO:0001662; P:behavioral fear response; ISO:RGD.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0008219; P:cell death; ISS:UniProtKB.
DR   GO; GO:0071300; P:cellular response to retinoic acid; ISO:RGD.
DR   GO; GO:0035640; P:exploration behavior; ISO:RGD.
DR   GO; GO:0042711; P:maternal behavior; ISO:RGD.
DR   GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; ISO:RGD.
DR   GO; GO:0050768; P:negative regulation of neurogenesis; ISO:RGD.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:RGD.
DR   GO; GO:0007614; P:short-term memory; ISO:RGD.
DR   GO; GO:0035176; P:social behavior; ISO:RGD.
DR   GO; GO:0071625; P:vocalization behavior; ISO:RGD.
DR   InterPro; IPR033237; BRINP.
DR   InterPro; IPR020864; MACPF.
DR   PANTHER; PTHR15564; PTHR15564; 1.
DR   Pfam; PF19052; BRINP; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00457; MACPF; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Glycoprotein; Growth arrest; Reference proteome;
KW   Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..760
FT                   /note="BMP/retinoic acid-inducible neural-specific protein
FT                   1"
FT                   /id="PRO_0000045768"
FT   DOMAIN          68..251
FT                   /note="MACPF"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        433
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        443
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        553
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        599
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        630
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        676
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   760 AA;  88654 MW;  22A30E493BC265D3 CRC64;
     MNWRFVELLY FLFVWGRISV QPSHQEPAGT DQHVSKEFDW LISDRGPFHH SRSYLSFVER
     HRQGFTTRYK IYREFARWKV RNTAIERRDL VRHPVPLMPE FQRSIRLLGR RPTTQQFIDT
     IIKKYGTHLL ISATLGGEEA LTMYMDKSRL DRKSGNATQS VEALHQLASS YFVDRDGTMR
     RLHEIQISTG AIKVTETRTG LLGCNSYDNL DSVSSVLLQS TESKLHLQGL QIIFPQYLQE
     KFVQSALSYI MCNGEGEYVC QNSQCRCQCA EEFPQCNCPI TDIQIMEFTL ANMAKAWTEA
     YKDLENSDEF KSFMKRLPSN HFLTIGSIHQ HWGNDWDLQS RYKLLQSATE AQRQKIQRTA
     RKLFGLSVRC RHNPNHQLPR ERTIQQWLAR VQSLLYCNEN GFWGTFLESQ RSCVCHGSTT
     LCQRPIPCII GGNNSCAMCS LANISLCGSC NKGYKLYRGR CEPQNVDSER SEQFISFETD
     LDFQDLELKY LLQKMDSRLY VHTTFISNEI RLDTFFDLRW RKRMSLTLKS NKNRMDFIHM
     VIGMSMRICQ MRNSSLDPMF FVYVNPFSGS HSEGWNMPFG EFGYPRWEKI RLQNSQCYNW
     TLLLGNRWKT FFETVHIYLR SRTRLPTLRN ETGQGPVDLS DPSKRQFYIK ISDVQVFGYS
     LRFNADLLRS AVQQVNQSYT QGGQFYSSSS VMLLMLDIRD RINRLAPPVA PGKPQLDLFS
     CMLKHRLKLT NSEIIRVNHA LDLYNTEILK QSDQMTAKLC