BRNP2_HUMAN
ID BRNP2_HUMAN Reviewed; 783 AA.
AC Q9C0B6; O95560; Q6ZWC1; Q7LCZ9; Q8N360;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=BMP/retinoic acid-inducible neural-specific protein 2;
DE AltName: Full=DBCCR1-like protein 2;
DE Flags: Precursor;
GN Name=BRINP2; Synonyms=DBCCR1L2, FAM5B, KIAA1747;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Inazawa J., Imoto I.;
RT "Homo sapiens DBCCR1L2 mRNA for DBCCR1-like 2.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:347-355(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-783 (ISOFORM 1).
RA Rhodes S.;
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 578-783.
RC TISSUE=Brain;
RA Mei G., Yu W., Gibbs R.A.;
RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits neuronal cell proliferation by negative regulation
CC of the cell cycle transition. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9C0B6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9C0B6-2; Sequence=VSP_017026;
CC -!- SIMILARITY: Belongs to the BRINP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB21838.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB161694; BAD34946.1; -; mRNA.
DR EMBL; AB051534; BAB21838.1; ALT_INIT; mRNA.
DR EMBL; AK123336; BAC85583.1; -; mRNA.
DR EMBL; AL022143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028036; AAH28036.1; -; mRNA.
DR EMBL; AL035289; CAA22893.1; -; mRNA.
DR EMBL; AF131833; AAD20055.1; -; mRNA.
DR CCDS; CCDS1320.1; -. [Q9C0B6-1]
DR RefSeq; NP_066988.1; NM_021165.3. [Q9C0B6-1]
DR RefSeq; XP_005245436.1; XM_005245379.1. [Q9C0B6-1]
DR AlphaFoldDB; Q9C0B6; -.
DR BioGRID; 121768; 38.
DR IntAct; Q9C0B6; 7.
DR MINT; Q9C0B6; -.
DR STRING; 9606.ENSP00000354481; -.
DR TCDB; 1.C.39.17.2; the membrane attack complex/perforin (macpf) family.
DR GlyGen; Q9C0B6; 6 sites.
DR iPTMnet; Q9C0B6; -.
DR PhosphoSitePlus; Q9C0B6; -.
DR BioMuta; BRINP2; -.
DR DMDM; 85700961; -.
DR jPOST; Q9C0B6; -.
DR MassIVE; Q9C0B6; -.
DR PaxDb; Q9C0B6; -.
DR PeptideAtlas; Q9C0B6; -.
DR PRIDE; Q9C0B6; -.
DR ProteomicsDB; 79991; -. [Q9C0B6-1]
DR ProteomicsDB; 79992; -. [Q9C0B6-2]
DR Antibodypedia; 55637; 41 antibodies from 10 providers.
DR DNASU; 57795; -.
DR Ensembl; ENST00000361539.5; ENSP00000354481.4; ENSG00000198797.7. [Q9C0B6-1]
DR GeneID; 57795; -.
DR KEGG; hsa:57795; -.
DR MANE-Select; ENST00000361539.5; ENSP00000354481.4; NM_021165.4; NP_066988.1.
DR UCSC; uc001glf.3; human. [Q9C0B6-1]
DR CTD; 57795; -.
DR GeneCards; BRINP2; -.
DR HGNC; HGNC:13746; BRINP2.
DR HPA; ENSG00000198797; Tissue enhanced (adrenal gland, brain).
DR MIM; 619359; gene.
DR neXtProt; NX_Q9C0B6; -.
DR OpenTargets; ENSG00000198797; -.
DR PharmGKB; PA142671895; -.
DR VEuPathDB; HostDB:ENSG00000198797; -.
DR eggNOG; ENOG502QQZS; Eukaryota.
DR GeneTree; ENSGT00940000160314; -.
DR HOGENOM; CLU_018347_0_0_1; -.
DR InParanoid; Q9C0B6; -.
DR OMA; VQHRYQQ; -.
DR OrthoDB; 157712at2759; -.
DR PhylomeDB; Q9C0B6; -.
DR TreeFam; TF331600; -.
DR PathwayCommons; Q9C0B6; -.
DR SignaLink; Q9C0B6; -.
DR BioGRID-ORCS; 57795; 10 hits in 1052 CRISPR screens.
DR ChiTaRS; BRINP2; human.
DR GenomeRNAi; 57795; -.
DR Pharos; Q9C0B6; Tdark.
DR PRO; PR:Q9C0B6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9C0B6; protein.
DR Bgee; ENSG00000198797; Expressed in right frontal lobe and 112 other tissues.
DR Genevisible; Q9C0B6; HS.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0071300; P:cellular response to retinoic acid; IBA:GO_Central.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IBA:GO_Central.
DR InterPro; IPR033237; BRINP.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR15564; PTHR15564; 1.
DR Pfam; PF19052; BRINP; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell cycle; Glycoprotein; Growth arrest;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..783
FT /note="BMP/retinoic acid-inducible neural-specific protein
FT 2"
FT /id="PRO_0000045770"
FT DOMAIN 85..281
FT /note="MACPF"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 354
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 473
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 579
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 626
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 658
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..153
FT /note="MRWQCGTRFRGLRPAVAPWTALLALGLPGWVLAVSATAAAVVPEQHASVAGQ
FT HPLDWLLTDRGPFHRAQEYADFMERYRQGFTTRYRIYREFARWKVNNLALERKDFFSLP
FT LPLAPEFIRNIRLLGRRPNLQQVTENLIKKYGTHFLLSATLG -> MVRAGGRAWQQGL
FT HSLSAVSILAKGFMFLLVGDSRAESVTNTLVLFTI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_017026"
FT VARIANT 71
FT /note="Y -> C (in dbSNP:rs16850984)"
FT /id="VAR_049022"
FT VARIANT 390
FT /note="L -> V (in dbSNP:rs3176443)"
FT /id="VAR_049023"
SQ SEQUENCE 783 AA; 89005 MW; B8362095ADC97FCD CRC64;
MRWQCGTRFR GLRPAVAPWT ALLALGLPGW VLAVSATAAA VVPEQHASVA GQHPLDWLLT
DRGPFHRAQE YADFMERYRQ GFTTRYRIYR EFARWKVNNL ALERKDFFSL PLPLAPEFIR
NIRLLGRRPN LQQVTENLIK KYGTHFLLSA TLGGEESLTI FVDKQKLGRK TETTGGASII
GGSGNSTAVS LETLHQLAAS YFIDRESTLR RLHHIQIATG AIKVTETRTG PLGCSNYDNL
DSVSSVLVQS PENKVQLLGL QVLLPEYLRE RFVAAALSYI TCSSEGELVC KENDCWCKCS
PTFPECNCPD ADIQAMEDSL LQIQDSWATH NRQFEESEEF QALLKRLPDD RFLNSTAISQ
FWAMDTSLQH RYQQLGAGLK VLFKKTHRIL RRLFNLCKRC HRQPRFRLPK ERSLSYWWNR
IQSLLYCGES TFPGTFLEQS HSCTCPYDQS SCQGPIPCAL GEGPACAHCA PDNSTRCGSC
NPGYVLAQGL CRPEVAESLE NFLGLETDLQ DLELKYLLQK QDSRIEVHSI FISNDMRLGS
WFDPSWRKRM LLTLKSNKYK PGLVHVMLAL SLQICLTKNS TLEPVMAIYV NPFGGSHSES
WFMPVNEGSF PDWERTNVDA AAQCQNWTIT LGNRWKTFFE TVHVYLRSRI KSLDDSSNET
IYYEPLEMTD PSKNLGYMKI NTLQVFGYSL PFDPDAIRDL ILQLDYPYTQ GSQDSALLQL
IELRDRVNQL SPPGKVRLDL FSCLLRHRLK LANNEVGRIQ SSLRAFNSKL PNPVEYETGK
LCS
