ID   BRNP2_RAT               Reviewed;         783 AA.
AC   Q8K1M8;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=BMP/retinoic acid-inducible neural-specific protein 2;
DE   Flags: Precursor;
GN   Name=Brinp2; Synonyms=Fam5b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=15193423; DOI=10.1016/j.molbrainres.2004.04.001;
RA   Kawano H., Nakatani T., Mori T., Ueno S., Fukaya M., Abe A., Kobayashi M.,
RA   Toda F., Watanabe M., Matsuoka I.;
RT   "Identification and characterization of novel developmentally regulated
RT   neural-specific proteins, BRINP family.";
RL   Brain Res. Mol. Brain Res. 125:60-75(2004).
CC   -!- FUNCTION: Inhibits neuronal cell proliferation by negative regulation
CC       of the cell cycle transition. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in olfactory bulb, cerebellum and
CC       neuronal layers in hippocampus. {ECO:0000269|PubMed:15193423}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from 11.5 dpc.
CC       {ECO:0000269|PubMed:15193423}.
CC   -!- SIMILARITY: Belongs to the BRINP family. {ECO:0000305}.
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DR   EMBL; AB077853; BAC03099.1; -; mRNA.
DR   RefSeq; NP_775138.1; NM_173115.1.
DR   AlphaFoldDB; Q8K1M8; -.
DR   STRING; 10116.ENSRNOP00000007455; -.
DR   GlyGen; Q8K1M8; 6 sites.
DR   iPTMnet; Q8K1M8; -.
DR   PhosphoSitePlus; Q8K1M8; -.
DR   jPOST; Q8K1M8; -.
DR   PaxDb; Q8K1M8; -.
DR   Ensembl; ENSRNOT00000007455; ENSRNOP00000007455; ENSRNOG00000005592.
DR   GeneID; 286895; -.
DR   KEGG; rno:286895; -.
DR   UCSC; RGD:708419; rat.
DR   CTD; 57795; -.
DR   RGD; 708419; Brinp2.
DR   eggNOG; ENOG502QQZS; Eukaryota.
DR   GeneTree; ENSGT00940000160314; -.
DR   InParanoid; Q8K1M8; -.
DR   OrthoDB; 157712at2759; -.
DR   PhylomeDB; Q8K1M8; -.
DR   PRO; PR:Q8K1M8; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   GO; GO:0030425; C:dendrite; IDA:RGD.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:RGD.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0071300; P:cellular response to retinoic acid; ISO:RGD.
DR   GO; GO:0045786; P:negative regulation of cell cycle; IMP:RGD.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; ISO:RGD.
DR   GO; GO:0007399; P:nervous system development; IEP:RGD.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:RGD.
DR   InterPro; IPR033237; BRINP.
DR   InterPro; IPR020864; MACPF.
DR   PANTHER; PTHR15564; PTHR15564; 1.
DR   Pfam; PF19052; BRINP; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00457; MACPF; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Glycoprotein; Growth arrest; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..783
FT                   /note="BMP/retinoic acid-inducible neural-specific protein
FT                   2"
FT                   /id="PRO_0000045773"
FT   DOMAIN          85..281
FT                   /note="MACPF"
FT   CARBOHYD        185
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        354
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        473
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        579
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        626
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        658
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   783 AA;  89139 MW;  2FF2F9532F62975D CRC64;
     MRWPCSSRFR GLWPEAAPWA VLLALGVPGW VLAVSATVAA VVPEQHVSSA GQAPLDWLLT
     DRGPFHRAQE YADFMERYRQ GFTTRYRIYR EFARWKVNNL ALERKDFFSL PLPLAPEFVR
     NIRLLGRRPN LQQVTENLIK KYGTHFLLSA TLGGEESLTI FVDKRKLSRK SETLGGVPVV
     GGTGNSSAVS LETLHQLAAS YFIDRESTLR RLHHIQIATG AIKVTETRTG PLGCSNYDNL
     DSVSSVLVQS PENKVQLLGL QVLLPEHLRE RFVAAALSYI TCSSEGELVC RENDCWCKCS
     PTFPECNCPD ADIQAMEDSL LQIQDSWATH NRQFEESEEF QTLLKRLPSD RFLNSTAISQ
     YWTMDANLQH RYQQLGASLK VLLKKMHRIV RRLFNLCKRC HRQPRFRLPK ERSLSFWWNR
     IQSLLYCGES TFPGTFLEQS HSCTCPYDQS SCQGPIPCAL GEGPACAHCA SDNTTRCGSC
     NPGYVLAQGL CRPEVAESLE NFLGLETDLQ DLELKYLLQK RDSRIEVHSI FISNDMRLGS
     WFDPSWRKRM LLTLKSNKYK PGLVHVMLAL SLQICLTKNS TLEPVMAIYV NPFGGSHSES
     WFMPVNEGSF PDWERTNVDA AAQCQNWTIT LGNRWKTFFE TVHVYLRSRI KSLDDSSNET
     IYYEPLEMTD PSKNLGYMKI NTLQVFGYSL PFDPDAIRDL ILQLDYPYTQ GSQDSALLQL
     IELRDRVNQL SPPGKVRLDL FSCLLRHRLK LANNEVGRIQ SSLRAFNSKL PNPVEYETGK
     LCS