BRNP3_MOUSE
ID BRNP3_MOUSE Reviewed; 766 AA.
AC Q499E0; Q8K0R9;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=BMP/retinoic acid-inducible neural-specific protein 3;
DE Flags: Precursor;
GN Name=Brinp3; Synonyms=Fam5c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CD-1; TISSUE=Eye, and Neural stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=17138656; DOI=10.1210/en.2006-0905;
RA Shorts-Cary L., Xu M., Ertel J., Kleinschmidt-Demasters B.K., Lillehei K.,
RA Matsuoka I., Nielsen-Preiss S., Wierman M.E.;
RT "Bone morphogenetic protein and retinoic acid-inducible neural specific
RT protein-3 is expressed in gonadotrope cell pituitary adenomas and induces
RT proliferation, migration, and invasion.";
RL Endocrinology 148:967-975(2007).
RN [3]
RP FUNCTION, INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=20025061; DOI=10.1002/jnr.22315;
RA Terashima M., Kobayashi M., Motomiya M., Inoue N., Yoshida T., Okano H.,
RA Iwasaki N., Minami A., Matsuoka I.;
RT "Analysis of the expression and function of BRINP family genes during
RT neuronal differentiation in mouse embryonic stem cell-derived neural stem
RT cells.";
RL J. Neurosci. Res. 88:1387-1393(2010).
CC -!- FUNCTION: Inhibits neuronal cell proliferation by negative regulation
CC of the cell cycle transition. Promotes pituitary gonadotrope cell
CC proliferation, migration and invasion, when overexpressed. May play a
CC role in cell pituitary tumor development.
CC {ECO:0000269|PubMed:20025061}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Mitochondrion
CC {ECO:0000269|PubMed:17138656}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain. Weakly expressed in
CC embryonic stem (ES) cells. Expressed in ES-derived neural stem cells
CC (NSCs) and neuronal cells. {ECO:0000269|PubMed:17138656,
CC ECO:0000269|PubMed:20025061}.
CC -!- INDUCTION: Up-regulated upon differentiation into neuronal cells in the
CC presence of retinoic acid and BDNF. Down-regulated upon differentiation
CC into astroglial cells. Down-regulated in gonadotrope cells by bone
CC morphogenetic protein and retinoic acid. {ECO:0000269|PubMed:17138656,
CC ECO:0000269|PubMed:20025061}.
CC -!- SIMILARITY: Belongs to the BRINP family. {ECO:0000305}.
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DR EMBL; BC030498; AAH30498.1; -; mRNA.
DR EMBL; BC099956; AAH99956.1; -; mRNA.
DR CCDS; CCDS15351.1; -.
DR RefSeq; NP_001139279.1; NM_001145807.1.
DR RefSeq; NP_705767.3; NM_153539.3.
DR RefSeq; XP_006529430.1; XM_006529367.3.
DR RefSeq; XP_006529431.1; XM_006529368.3.
DR RefSeq; XP_017175281.1; XM_017319792.1.
DR AlphaFoldDB; Q499E0; -.
DR STRING; 10090.ENSMUSP00000074201; -.
DR GlyGen; Q499E0; 6 sites.
DR iPTMnet; Q499E0; -.
DR PhosphoSitePlus; Q499E0; -.
DR MaxQB; Q499E0; -.
DR PaxDb; Q499E0; -.
DR PeptideAtlas; Q499E0; -.
DR PRIDE; Q499E0; -.
DR ProteomicsDB; 265381; -.
DR Antibodypedia; 55879; 88 antibodies from 16 providers.
DR DNASU; 215378; -.
DR Ensembl; ENSMUST00000074622; ENSMUSP00000074201; ENSMUSG00000035131.
DR Ensembl; ENSMUST00000166814; ENSMUSP00000126074; ENSMUSG00000035131.
DR GeneID; 215378; -.
DR KEGG; mmu:215378; -.
DR UCSC; uc007cxo.2; mouse.
DR CTD; 339479; -.
DR MGI; MGI:2443035; Brinp3.
DR VEuPathDB; HostDB:ENSMUSG00000035131; -.
DR eggNOG; ENOG502QQZS; Eukaryota.
DR GeneTree; ENSGT00940000156099; -.
DR HOGENOM; CLU_018347_0_0_1; -.
DR InParanoid; Q499E0; -.
DR OMA; CQCGPRF; -.
DR OrthoDB; 157712at2759; -.
DR PhylomeDB; Q499E0; -.
DR TreeFam; TF331600; -.
DR BioGRID-ORCS; 215378; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Brinp3; mouse.
DR PRO; PR:Q499E0; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q499E0; protein.
DR Bgee; ENSMUSG00000035131; Expressed in lumbar subsegment of spinal cord and 72 other tissues.
DR ExpressionAtlas; Q499E0; baseline and differential.
DR Genevisible; Q499E0; MM.
DR GO; GO:0030425; C:dendrite; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0071300; P:cellular response to retinoic acid; IDA:UniProtKB.
DR GO; GO:0045786; P:negative regulation of cell cycle; ISO:MGI.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; IDA:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:UniProtKB.
DR InterPro; IPR033237; BRINP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR15564; PTHR15564; 1.
DR Pfam; PF19052; BRINP; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF57184; SSF57184; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Glycoprotein; Growth arrest; Mitochondrion; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..766
FT /note="BMP/retinoic acid-inducible neural-specific protein
FT 3"
FT /id="PRO_0000045775"
FT DOMAIN 74..264
FT /note="MACPF"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 337
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 456
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 562
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 609
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 641
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 599
FT /note="T -> A (in Ref. 1; AAH99956)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 766 AA; 88483 MW; 15BC4F2DAF813B71 CRC64;
MIWRRRAGAE LSSLMALWEW IVLSLHCWVL AVAAVSDQHA TSPFDWLLSD KGPFHRSQEY
TDFVDRSRQG FSTRYKIYRE FGRWKVNNLA VERRNFLGSP LPLAPEFFRN IRLLGRRPTL
QQITENLIKK YGTHFLLSAT LGGEESLTIF VDKRKLSKRS EGSETSTNSS SVTLETLHQL
AASYFIDRDS TLRRLHHIQI ASTAIKVTET RTGPLGCSNY DNLDSVSSVL VQSPENKIQL
QGLQVLLPDY LQERFVQAAL SYIACNSEGE FICKDNDCWC HCGPKFPECN CPSMDIQAME
ENLLRITETW KAYNSDFEDS DEFKFFMKRL PMNYFLNTST IMHLWTMDSN FQRRYEQLEN
SMKQLFLKAH RIVHKLFSLS KRCHKQPLIS LPRQRTSTYW LTRIQSFLYC NENGLLGSFS
EETHSCTCPN DQVVCTAFLP CTVGDASACL TCAPDNRTRC GTCNTGYMLS QGLCKPEVAE
STDHYIGFET DLQDLEMKYL LQKTDRRIEV HAIFISNDMR LNSWFDPSWR KRMLLTLKSN
KYKSSLVHMI LGLSLQICLT KNSTLEPVLA VYVNPFGGSH SESWFMPVSE SSFPDWERTK
LDLPLQCYNW TLTLGNKWKT FFETVHIYLR SRIKANGPNS NESIYYEPLE FIDPSRNLGY
MKINNIQVFG YSMHFDPEAI RDLILQLDYP YTQGSQDSAL LQLLEIRDRV NKLSPPGQRR
LDLFSCLLRH RLKLSTSEVV RIQSALQAFN AKLPNTVDYD TTKLCS
