BRNP3_RAT
ID BRNP3_RAT Reviewed; 766 AA.
AC Q8K1M7;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=BMP/retinoic acid-inducible neural-specific protein 3;
DE Flags: Precursor;
GN Name=Brinp3; Synonyms=Fam5c;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15193423; DOI=10.1016/j.molbrainres.2004.04.001;
RA Kawano H., Nakatani T., Mori T., Ueno S., Fukaya M., Abe A., Kobayashi M.,
RA Toda F., Watanabe M., Matsuoka I.;
RT "Identification and characterization of novel developmentally regulated
RT neural-specific proteins, BRINP family.";
RL Brain Res. Mol. Brain Res. 125:60-75(2004).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=17138656; DOI=10.1210/en.2006-0905;
RA Shorts-Cary L., Xu M., Ertel J., Kleinschmidt-Demasters B.K., Lillehei K.,
RA Matsuoka I., Nielsen-Preiss S., Wierman M.E.;
RT "Bone morphogenetic protein and retinoic acid-inducible neural specific
RT protein-3 is expressed in gonadotrope cell pituitary adenomas and induces
RT proliferation, migration, and invasion.";
RL Endocrinology 148:967-975(2007).
CC -!- FUNCTION: Inhibits neuronal cell proliferation by negative regulation
CC of the cell cycle transition. Promotes pituitary gonadotrope cell
CC proliferation, migration and invasion, when overexpressed. May play a
CC role in cell pituitary tumor development (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Mitochondrion
CC {ECO:0000269|PubMed:17138656}.
CC -!- TISSUE SPECIFICITY: Expressed in olfactory bulb, cerebellum and
CC neuronal layers in hippocampus. {ECO:0000269|PubMed:15193423}.
CC -!- DEVELOPMENTAL STAGE: Expressed from 11.5 dpc.
CC {ECO:0000269|PubMed:15193423}.
CC -!- SIMILARITY: Belongs to the BRINP family. {ECO:0000305}.
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DR EMBL; AB077854; BAC03100.1; -; mRNA.
DR RefSeq; NP_775144.1; NM_173121.1.
DR RefSeq; XP_017454169.1; XM_017598680.1.
DR RefSeq; XP_017454170.1; XM_017598681.1.
DR RefSeq; XP_017454171.1; XM_017598682.1.
DR RefSeq; XP_017454172.1; XM_017598683.1.
DR RefSeq; XP_017454173.1; XM_017598684.1.
DR RefSeq; XP_017454174.1; XM_017598685.1.
DR AlphaFoldDB; Q8K1M7; -.
DR STRING; 10116.ENSRNOP00000003788; -.
DR GlyGen; Q8K1M7; 6 sites.
DR PhosphoSitePlus; Q8K1M7; -.
DR PaxDb; Q8K1M7; -.
DR PRIDE; Q8K1M7; -.
DR Ensembl; ENSRNOT00000003788; ENSRNOP00000003788; ENSRNOG00000002811.
DR GeneID; 286901; -.
DR KEGG; rno:286901; -.
DR UCSC; RGD:708421; rat.
DR CTD; 339479; -.
DR RGD; 708421; Brinp3.
DR eggNOG; ENOG502QQZS; Eukaryota.
DR GeneTree; ENSGT00940000156099; -.
DR HOGENOM; CLU_018347_0_0_1; -.
DR InParanoid; Q8K1M7; -.
DR OMA; CQCGPRF; -.
DR OrthoDB; 157712at2759; -.
DR PhylomeDB; Q8K1M7; -.
DR TreeFam; TF331600; -.
DR PRO; PR:Q8K1M7; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Bgee; ENSRNOG00000002811; Expressed in frontal cortex and 2 other tissues.
DR GO; GO:0030425; C:dendrite; IDA:RGD.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:RGD.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB.
DR GO; GO:0045786; P:negative regulation of cell cycle; IMP:RGD.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEP:RGD.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
DR InterPro; IPR033237; BRINP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR15564; PTHR15564; 1.
DR Pfam; PF19052; BRINP; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF57184; SSF57184; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Glycoprotein; Growth arrest; Mitochondrion; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..766
FT /note="BMP/retinoic acid-inducible neural-specific protein
FT 3"
FT /id="PRO_0000045776"
FT DOMAIN 74..264
FT /note="MACPF"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 337
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 456
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 562
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 609
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 641
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 766 AA; 88497 MW; 0D2170F602E1EE5D CRC64;
MIWRRRAGAE LSSLMALWEW IVLSLHCWVL AVAAVSDQHA TSPFDWLLSD KGPFHRSQEY
TDFVDRSRQG FSTRYKIYRE FGRWKVNNLA VERRNFLGSP LPLAPEFFRN IRLLGRRPTL
QQITENLIKK YGTHFLLSAT LGGEESLTIF VDKRKLSKRP EGSETSTNSS SVTLETLHQL
AASYFIDRDS TLRRLHHIQI ASTAIKVTET RTGPLGCSNY DNLDSVSSVL VQSPENKIQL
QGLQVLLPDY LQERFVQAAL SYIACNSEGE FICKENDCWC LCGPKFPECN CPSMDIQAME
ENLLRITETW KAYNSDFEDS DEFKFFMKRL PMNYFLNTST IMHLWTMDSN FQRRYEQLEN
SMKQLFLKAH RIVHKLFSLS KRCHKQPLIS LPRQRTSTYW LTRIQSFLYC NENGLLGSFS
EETHSCTCPN DQVVCTAFLP CTVGDASACL TCAPDNRTRC GTCNTGYMLS QGLCKPEVAE
STDHYIGFET DLQDLEMKYL LQKTDRRIEV HAIFISNDMR LNSWFDPSWR KRMLLTLKSN
KYKSSLVHMI LGLSLQICLT KNSTLEPVLA VYINPFGGSH SESWFMPVSE SSFPDWERTK
LDLPLQCYNW TLTLGNKWKT FFETVHIYLR SRIKANGPNS NESIYYEPLE FIDPSRNLGY
MKINNIQVFG YSMHFDPEAI RDLILQLDYP YTQGSQDSAL LQLLEIRDRV NKLSPPGQRR
LDLFSCLLRH RLKLSTSEVV RIQSALQAFN AKLPNTVDYD TTKLCS
