ID   BRNQL_STAAR             Reviewed;         447 AA.
AC   Q6GH01;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Putative branched-chain amino acid carrier protein SAR1419;
GN   OrderedLocusNames=SAR1419;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Component of the transport system for branched-chain amino
CC       acids (leucine, isoleucine and valine), which is coupled to a proton
CC       motive force (Potential). Contributes to NaCl tolerance (By
CC       similarity). {ECO:0000250, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the branched chain amino acid transporter
CC       family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG40416.1; -; Genomic_DNA.
DR   RefSeq; WP_001039267.1; NC_002952.2.
DR   AlphaFoldDB; Q6GH01; -.
DR   KEGG; sar:SAR1419; -.
DR   HOGENOM; CLU_036807_0_1_9; -.
DR   OMA; IWPAGPI; -.
DR   OrthoDB; 1533843at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015658; F:branched-chain amino acid transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR004685; Brnchd-chn_aa_trnsp_Livcs.
DR   PANTHER; PTHR30588; PTHR30588; 1.
DR   Pfam; PF05525; Branch_AA_trans; 1.
DR   TIGRFAMs; TIGR00796; livcs; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..447
FT                   /note="Putative branched-chain amino acid carrier protein
FT                   SAR1419"
FT                   /id="PRO_0000294013"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   447 AA;  48893 MW;  4CDC138B4A8400D9 CRC64;
     MNKNTWVIGF TLFAMFFGAG NLIFPPNLGL DSGQFFWPAI LAFVLTGIGL PLLGVIVGAL
     DKEGYIGALN KISPKFSILF LIIIYLTIGP LFAIPRTAST SFEMTITPII HSNSSIALFI
     FTIIYFIVVL YICLNPSKLI DRIGSLLTPL LLITILAMII KAYLDFSGNS AGKGNEALYH
     SNFSSFAEGF TQGYLTMDAI AAIAFSMIVV NAVKLTGITK TNQIFKQTLT AGLIAAIALI
     FIYISLGYIG NHMPVSDMKL NELKSHDRNI GTYLLTTMAS TGFGSFGKYL LGIIVALACL
     TTACGLIVAV SEYFHRIVPK VSYKAFVLVF ILMSFIIANQ GLNAVISMSI PVLSIVYPVA
     ITVVLLILIA KFIPTKRITQ QIPVIIVFIL SIFSVISKLG WLKINFIESL PLRAYSLEWF
     PVAIIATILG YLVGIFVKQD PIKYQQE