BRNQ_BACSU
ID BRNQ_BACSU Reviewed; 440 AA.
AC P94499; O07082;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Branched-chain amino acid transport system carrier protein BrnQ;
DE AltName: Full=Branched-chain amino acid uptake carrier BrnQ;
GN Name=brnQ; Synonyms=yrdJ; OrderedLocusNames=BSU26690;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / SMY;
RX PubMed=9023181; DOI=10.1128/jb.179.4.1035-1043.1997;
RA Belitsky B.R., Sonenshein A.L.;
RT "Altered transcription activation specificity of a mutant form of Bacillus
RT subtilis GltR, a LysR family member.";
RL J. Bacteriol. 179:1035-1043(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9308178; DOI=10.1099/00221287-143-9-2939;
RA Sorokin A., Bolotin A., Purnelle B., Hilbert H., Lauber J.,
RA Duesterhoeft A., Ehrlich S.D.;
RT "Sequence of the Bacillus subtilis genome region in the vicinity of the lev
RT operon reveals two new extracytoplasmic function RNA polymerase sigma
RT factors SigV and SigZ.";
RL Microbiology 143:2939-2943(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: Component of the transport system for branched-chain amino
CC acids (leucine, isoleucine and valine) Which is coupled to a proton
CC motive force. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the branched chain amino acid transporter
CC family. {ECO:0000305}.
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DR EMBL; U79494; AAB47961.1; -; Genomic_DNA.
DR EMBL; U93876; AAB80903.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14610.1; -; Genomic_DNA.
DR PIR; D69596; D69596.
DR RefSeq; NP_390546.1; NC_000964.3.
DR RefSeq; WP_003246136.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P94499; -.
DR STRING; 224308.BSU26690; -.
DR PaxDb; P94499; -.
DR PRIDE; P94499; -.
DR EnsemblBacteria; CAB14610; CAB14610; BSU_26690.
DR GeneID; 936930; -.
DR KEGG; bsu:BSU26690; -.
DR PATRIC; fig|224308.179.peg.2899; -.
DR eggNOG; COG1114; Bacteria.
DR InParanoid; P94499; -.
DR OMA; HVFFKGF; -.
DR PhylomeDB; P94499; -.
DR BioCyc; BSUB:BSU26690-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015188; F:L-isoleucine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015190; F:L-leucine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005304; F:L-valine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015818; P:isoleucine transport; IBA:GO_Central.
DR GO; GO:0015820; P:leucine transport; IBA:GO_Central.
DR GO; GO:0015829; P:valine transport; IBA:GO_Central.
DR InterPro; IPR004685; Brnchd-chn_aa_trnsp_Livcs.
DR PANTHER; PTHR30588; PTHR30588; 1.
DR Pfam; PF05525; Branch_AA_trans; 1.
DR TIGRFAMs; TIGR00796; livcs; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..440
FT /note="Branched-chain amino acid transport system carrier
FT protein BrnQ"
FT /id="PRO_0000099771"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 331
FT /note="L -> V (in Ref. 1; AAB47961)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 440 AA; 47006 MW; 940B0F020BF3C6CB CRC64;
MSKKVSASYI IIIGLMLFAL FFGAGNLIFP PMLGQLAGKN VWVANAGFLV TGVGLPLLAI
TAFVFSGKQN LQSLASRVHP VFGIVFTTIL YLAIGPFFAI PRSGNVSFEI GVKPFLSNDA
SPVSLIIFTI LFFALACLLS LNPSKIIDIV GKFLTPIKLT FIGLLVAVAL IRPIGTIQAP
SKGYTSQAFF KGFQEGYLTL DALVAFVFGI IIVNALKEQG ASTKKQLIVV CAKAAAIAAV
LLAVMYTALS YMGASSVEEL GILENGAEVL AKVSSYYFGS YGSILLGLMI TVACLTTSVG
LITACSSFFH ELFPNISYKK IAVVLSVFST LVANIGLTQL IKVSMPVLLT MYPIAISLIF
LTFLHSVFKG KTEVYQGSLL FAFIISLFDG LKAAGIKIEV VNRIFTQILP MYNIGLGWLI
PAIAGGICGY ILSIFRTKTS
