ID   BRNQ_LACLM              Reviewed;         449 AA.
AC   A2RJ04;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Branched-chain amino acid transport system carrier protein {ECO:0000305};
GN   Name=brnQ {ECO:0000303|PubMed:23144255};
GN   OrderedLocusNames=llmg_0650 {ECO:0000312|EMBL:CAL97252.1};
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
RN   [2]
RP   FUNCTION.
RC   STRAIN=MG1363;
RX   PubMed=23144255; DOI=10.1128/jb.01948-12;
RA   Trip H., Mulder N.L., Lolkema J.S.;
RT   "Cloning, expression, and functional characterization of secondary amino
RT   acid transporters of Lactococcus lactis.";
RL   J. Bacteriol. 195:340-350(2013).
CC   -!- FUNCTION: Component of the transport system for branched-chain amino
CC       acids. Can transport isoleucine, leucine and valine.
CC       {ECO:0000269|PubMed:23144255}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the branched chain amino acid transporter
CC       family. {ECO:0000305}.
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DR   EMBL; AM406671; CAL97252.1; -; Genomic_DNA.
DR   RefSeq; WP_011834657.1; NZ_WJVF01000060.1.
DR   AlphaFoldDB; A2RJ04; -.
DR   STRING; 416870.llmg_0650; -.
DR   EnsemblBacteria; CAL97252; CAL97252; llmg_0650.
DR   KEGG; llm:llmg_0650; -.
DR   eggNOG; COG1114; Bacteria.
DR   HOGENOM; CLU_036807_0_1_9; -.
DR   OMA; HVFFKGF; -.
DR   PhylomeDB; A2RJ04; -.
DR   BioCyc; LLAC416870:LLMG_RS03390-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015658; F:branched-chain amino acid transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR004685; Brnchd-chn_aa_trnsp_Livcs.
DR   PANTHER; PTHR30588; PTHR30588; 1.
DR   Pfam; PF05525; Branch_AA_trans; 1.
DR   TIGRFAMs; TIGR00796; livcs; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..449
FT                   /note="Branched-chain amino acid transport system carrier
FT                   protein"
FT                   /id="PRO_0000442546"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   449 AA;  48900 MW;  1921464F677698B7 CRC64;
     MKEKLAGKDY LFIGSMLFGL FFGAGNLIFP IHMGQEAGDA ISQANFGFLV TAVGFPFLGI
     IALGISQSNG VFELATRVNR IYAYIFTILL YLVIGPFFAL PRLATTSFEI GISPFLSNKL
     QTPLLALFSI LFFGTAWFLS RKPTKLLDYI GKFLNPLFLV LLGLILIIAF SHPLGSVHQA
     EVGKLYQSSA FMNGFTQGYN TLDALAALAF GIIIITTIRQ RGVKNSKIIA KETIKAGLIS
     VGLMAIIYTC LSYLGAMSVG KFAISENGGI ALAQISNYYL GTFGMIILAL IVIIACLKTA
     VGLMSAFSET FVELFPKREY RFYLMIVSIL PCIFANIGLT KIIELSVPVL MFLYPLAITL
     ILLALLGPVF QHSKLVYQIT TAFTLLAAIA DGLNALPNPL KSLKPIAAIL NFSKDSLPFF
     SLGMGWILLA VLGFIIGCLV HFLKRITNK