BRNQ_SALTI
ID BRNQ_SALTI Reviewed; 439 AA.
AC P0A1W9; P14931;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Branched-chain amino acid transport system 2 carrier protein;
DE AltName: Full=LIV-II;
GN Name=brnQ; OrderedLocusNames=STY0435, t2465;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Component of the LIV-II transport system for branched-chain
CC amino acids. This LIV-II transport system may be H(+)-coupled (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the branched chain amino acid transporter
CC family. {ECO:0000305}.
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DR EMBL; AL513382; CAD08854.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70055.1; -; Genomic_DNA.
DR RefSeq; NP_454993.1; NC_003198.1.
DR RefSeq; WP_000149625.1; NZ_WSUR01000017.1.
DR AlphaFoldDB; P0A1W9; -.
DR STRING; 220341.16501667; -.
DR EnsemblBacteria; AAO70055; AAO70055; t2465.
DR KEGG; stt:t2465; -.
DR KEGG; sty:STY0435; -.
DR PATRIC; fig|220341.7.peg.433; -.
DR eggNOG; COG1114; Bacteria.
DR HOGENOM; CLU_036807_0_0_6; -.
DR OMA; IWPAGPI; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015658; F:branched-chain amino acid transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR004685; Brnchd-chn_aa_trnsp_Livcs.
DR PANTHER; PTHR30588; PTHR30588; 1.
DR Pfam; PF05525; Branch_AA_trans; 1.
DR TIGRFAMs; TIGR00796; livcs; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..439
FT /note="Branched-chain amino acid transport system 2 carrier
FT protein"
FT /id="PRO_0000099767"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..43
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..79
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..118
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..189
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..226
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..277
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 338
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 391..404
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 426..439
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 439 AA; 46221 MW; AC715567B4BA377A CRC64;
MTHQLKSRDI IALGFMTFAL FVGAGNIIFP PMVGLQAGEH VWTAAIGFLI TAVGLPVLTV
VALAKVGGGV DSLSTPIGKV AGLLLATVCY LAVGPLFATP RTATVSFEVG IAPLTGDSAM
PLLIYSVVYF AIVILVSLYP GKLLDTVGNF LAPLKIIALV ILSVAAIVWP AGPISNALDA
YQNAAFSNGF VNGYLTMDTL GAMVFGIVIV NAARSRGVTE ARLLTRYTVW AGLMAGVGLT
LLYLALFRLG SDSATLVDQS ANGAAILHAY VQHTFGGAGS FLLAALIFIA CLVTAVGLTC
ACAEFFAQYI PLSYRTLVFI LGGFSMVVSN LGLSHLIQIS IPVLTAIYPP CIALVVLSFT
RSWWHNSTRI IAPAMFISLL FGILDGIKAS AFGDMLPAWS QRLPLAEQGL AWLMPTVVMV
ILAIIWDRAA GRQVTSSAH
