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BRNQ_SALTY
ID   BRNQ_SALTY              Reviewed;         439 AA.
AC   P0A1W8; P14931;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Branched-chain amino acid transport system 2 carrier protein;
DE   AltName: Full=LIV-II;
GN   Name=brnQ; OrderedLocusNames=STM0399;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3078876; DOI=10.1266/jjg.63.343;
RA   Ohnishi K., Hasegawa A., Matsubara K., Date T., Okada T., Kiritani K.;
RT   "Cloning and nucleotide sequence of the brnQ gene, the structural gene for
RT   a membrane-associated component of the LIV-II transport system for
RT   branched-chain amino acids in Salmonella typhimurium.";
RL   Jpn. J. Genet. 63:343-357(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Component of the LIV-II transport system for branched-chain
CC       amino acids. This LIV-II transport system may be H(+)-coupled.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the branched chain amino acid transporter
CC       family. {ECO:0000305}.
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DR   EMBL; D00332; BAA00239.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL19353.1; -; Genomic_DNA.
DR   PIR; A93044; JQ0007.
DR   RefSeq; NP_459394.1; NC_003197.2.
DR   RefSeq; WP_000149625.1; NC_003197.2.
DR   AlphaFoldDB; P0A1W8; -.
DR   STRING; 99287.STM0399; -.
DR   PaxDb; P0A1W8; -.
DR   EnsemblBacteria; AAL19353; AAL19353; STM0399.
DR   GeneID; 1251918; -.
DR   KEGG; stm:STM0399; -.
DR   PATRIC; fig|99287.12.peg.426; -.
DR   HOGENOM; CLU_036807_0_0_6; -.
DR   OMA; IWPAGPI; -.
DR   PhylomeDB; P0A1W8; -.
DR   BioCyc; SENT99287:STM0399-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015188; F:L-isoleucine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015190; F:L-leucine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005304; F:L-valine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015818; P:isoleucine transport; IBA:GO_Central.
DR   GO; GO:0015820; P:leucine transport; IBA:GO_Central.
DR   GO; GO:0015829; P:valine transport; IBA:GO_Central.
DR   InterPro; IPR004685; Brnchd-chn_aa_trnsp_Livcs.
DR   PANTHER; PTHR30588; PTHR30588; 1.
DR   Pfam; PF05525; Branch_AA_trans; 1.
DR   TIGRFAMs; TIGR00796; livcs; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..439
FT                   /note="Branched-chain amino acid transport system 2 carrier
FT                   protein"
FT                   /id="PRO_0000099768"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..43
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..79
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        101..118
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        140..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..189
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..226
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        248..277
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        299..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        338
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        360..369
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        391..404
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        426..439
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        14
FT                   /note="G -> A (in Ref. 1; BAA00239)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        24
FT                   /note="A -> R (in Ref. 1; BAA00239)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        45
FT                   /note="A -> R (in Ref. 1; BAA00239)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        199..201
FT                   /note="TLG -> DWV (in Ref. 1; BAA00239)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   439 AA;  46221 MW;  AC715567B4BA377A CRC64;
     MTHQLKSRDI IALGFMTFAL FVGAGNIIFP PMVGLQAGEH VWTAAIGFLI TAVGLPVLTV
     VALAKVGGGV DSLSTPIGKV AGLLLATVCY LAVGPLFATP RTATVSFEVG IAPLTGDSAM
     PLLIYSVVYF AIVILVSLYP GKLLDTVGNF LAPLKIIALV ILSVAAIVWP AGPISNALDA
     YQNAAFSNGF VNGYLTMDTL GAMVFGIVIV NAARSRGVTE ARLLTRYTVW AGLMAGVGLT
     LLYLALFRLG SDSATLVDQS ANGAAILHAY VQHTFGGAGS FLLAALIFIA CLVTAVGLTC
     ACAEFFAQYI PLSYRTLVFI LGGFSMVVSN LGLSHLIQIS IPVLTAIYPP CIALVVLSFT
     RSWWHNSTRI IAPAMFISLL FGILDGIKAS AFGDMLPAWS QRLPLAEQGL AWLMPTVVMV
     ILAIIWDRAA GRQVTSSAH
 
 
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