BRO1_GIBZE
ID BRO1_GIBZE Reviewed; 995 AA.
AC Q4IBS9; A0A0E0SLK0; A0A1C3YK14; I1RMX5;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Vacuolar protein-sorting protein BRO1;
DE AltName: Full=BRO domain-containing protein 1;
GN Name=BRO1; ORFNames=FGRAMPH1_01T17641, FGRRES_05329, FGSG_05329;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Involved in concentration and sorting of cargo proteins of
CC the multivesicular body (MVB) for incorporation into intralumenal
CC vesicles. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BRO1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ESU11271.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS231665; ESU11271.1; ALT_SEQ; Genomic_DNA.
DR EMBL; HG970334; SCB64736.1; -; Genomic_DNA.
DR RefSeq; XP_011323847.1; XM_011325545.1.
DR AlphaFoldDB; Q4IBS9; -.
DR SMR; Q4IBS9; -.
DR STRING; 5518.FGSG_05329P0; -.
DR EnsemblFungi; ESU11271; ESU11271; FGSG_05329.
DR GeneID; 23552515; -.
DR KEGG; fgr:FGSG_05329; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G17641; -.
DR eggNOG; KOG2220; Eukaryota.
DR HOGENOM; CLU_003661_0_0_1; -.
DR InParanoid; Q4IBS9; -.
DR Proteomes; UP000070720; Chromosome 3.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0071985; P:multivesicular body sorting pathway; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.280; -; 1.
DR InterPro; IPR025304; ALIX_V_dom.
DR InterPro; IPR045251; BRO1-like.
DR InterPro; IPR004328; BRO1_dom.
DR InterPro; IPR038499; BRO1_sf.
DR PANTHER; PTHR23030; PTHR23030; 1.
DR Pfam; PF13949; ALIX_LYPXL_bnd; 1.
DR Pfam; PF03097; BRO1; 1.
DR SMART; SM01041; BRO1; 1.
DR PROSITE; PS51180; BRO1; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Endosome; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..995
FT /note="Vacuolar protein-sorting protein BRO1"
FT /id="PRO_0000218866"
FT DOMAIN 5..407
FT /note="BRO1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT REGION 755..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 720..786
FT /evidence="ECO:0000255"
FT COMPBIAS 767..784
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..947
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 112056 MW; B5249D334DAAB41B CRC64;
MAQSPMISVP LKATNEIDWV EPLKRYIRDT YGDDPERYAE ECATLNRLRQ DVRGAGKDST
SGRDMLYRYY GQLELLDLRF PVDEQHIKIS FTWFDAFTHK STAQYSLAFE KASIIFNISA
VLSCHAAAQD RGEESALKTA YHNFQASAGM FTYINENFLH APSSDLSRET VKALIHVMLA
QAQEVFLEKQ VADKKKPALL AKLASQAGYL YSQALEGVQE NVTKAIFEKV WLLMTQIKSN
LLNSMAQYYQ ALADEEQDKH GIAVGRLQTA ETQAKEAERV ARSFPNSVPM SSNLSADCGG
FLQELTKRHL STVQSQLQSA LKDNDYIYHK EVPAEASLEA VAKLPAAKPI PVSELYAGQD
IQRITGPDLF AKIVPFAVTE SASLYDEEKA KLVRAEAERV DTANGEMAAS LDYLRLPGAL
QVLKGGFDQD ILPDEDFRQW CEDVSDQENP VTLFDSLRTE KDSILSILDK STKQLDMEEG
VCEKMRSKYE NEWTQQPSSR LTTTLRGDIR HYREALDEAS RSDNQLAGKL RQNEMDFDEM
RRAAKSGEAD QLFQRAVAQA RARGSNATSP AGLEPNLLDD DFDEGPSVID QINRVEDILK
KLNSIKRERN QVLKDLKEKA HNDDISQILI LNKKSISNYE AQLFEQELEK FRPHQNRLLQ
ANHKQSALMK ELTSAFNRLL QDKRVQSEQS KYETIQRQRS SVINRYKRAY QEFLDLVAGL
QSAKNWYAEM RETVESLEKN VDSFVNNRRS EGAQLLNQIE QERSSNKNSQ AEMERERLRG
LMDRMSMDPN KSSPQPQQNR PTPPSQYQQS QAPRYPQTNY QGQYQQPNSP PPQQAQQQAY
QNFSPPPTTT TTQSFGPPPI NTFVQPTYNP SQYGRTPGPT SPPPNQTSFN IGGYRGPASP
PPNQSTFGQS QSFGGYGASS TPQTQGGYVP PGFVPPPPPP GPPPLGPQQT FHYGNQPNSA
HPNSAYPQSA MPPQQQQQQQ QQQQNDPWAG LNAWK
