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BRO1_SCHPO
ID   BRO1_SCHPO              Reviewed;         775 AA.
AC   O13783;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Vacuolar protein-sorting protein bro1;
DE   AltName: Full=BRO domain-containing protein 1;
GN   Name=bro1; ORFNames=SPAC17G6.05c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Involved in concentration and sorting of cargo proteins of
CC       the multivesicular body (MVB) for incorporation into intralumenal
CC       vesicles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRO1 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB16216.1; -; Genomic_DNA.
DR   PIR; T37837; T37837.
DR   RefSeq; NP_594252.1; NM_001019675.2.
DR   AlphaFoldDB; O13783; -.
DR   SMR; O13783; -.
DR   BioGRID; 278882; 20.
DR   STRING; 4896.SPAC17G6.05c.1; -.
DR   iPTMnet; O13783; -.
DR   MaxQB; O13783; -.
DR   PaxDb; O13783; -.
DR   PRIDE; O13783; -.
DR   EnsemblFungi; SPAC17G6.05c.1; SPAC17G6.05c.1:pep; SPAC17G6.05c.
DR   GeneID; 2542419; -.
DR   KEGG; spo:SPAC17G6.05c; -.
DR   PomBase; SPAC17G6.05c; bro1.
DR   VEuPathDB; FungiDB:SPAC17G6.05c; -.
DR   eggNOG; KOG2220; Eukaryota.
DR   HOGENOM; CLU_360983_0_0_1; -.
DR   InParanoid; O13783; -.
DR   OMA; ANHKQSA; -.
DR   PhylomeDB; O13783; -.
DR   PRO; PR:O13783; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005768; C:endosome; ISO:PomBase.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISO:PomBase.
DR   Gene3D; 1.25.40.280; -; 1.
DR   InterPro; IPR025304; ALIX_V_dom.
DR   InterPro; IPR045251; BRO1-like.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   PANTHER; PTHR23030; PTHR23030; 1.
DR   Pfam; PF13949; ALIX_LYPXL_bnd; 1.
DR   Pfam; PF03097; BRO1; 1.
DR   SMART; SM01041; BRO1; 1.
DR   PROSITE; PS51180; BRO1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Endosome; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..775
FT                   /note="Vacuolar protein-sorting protein bro1"
FT                   /id="PRO_0000218869"
FT   DOMAIN          7..414
FT                   /note="BRO1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT   REGION          755..775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          574..601
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   775 AA;  86622 MW;  5478B33B96C8AF58 CRC64;
     MEKLATPFFY LNKKETKHSD WVEPFTTFVS RIYGNSVDVE DQIKAFNTLR ENAADVDDTV
     AGKDILYSYY GQLDYLSFRF PTGGNGINIS FEWSDILDPD ADFVKQSSLA FEKASVLFNL
     VSLLSRMAAN HASAYTVDDY KAAANCLQCA SGIAKLLRES FIHAPGRDLD SNFLLGIYNL
     FLGQAQECVL GHMSFSASDS NMNYSLAAKI ASSAATLYDS CVHAFESMEP ACNPNFIRLA
     SAKKAALEGF SSYFMARAQL EKSKQGLAIG YLQQAKSILS SAQKLFNGIK LSTDFIHKPS
     LSDYPQTIST FIKSSLSHLL KTAEKDNDFV FHDLVVKEVE LPKISPLQAL PPLPLEKLYG
     SQDGFETAKK IVGDDLFKAF VPSAVTTASS LYSEETAKVF RAEQAEVERQ NTQMATVFAS
     LDLSRLQEIT HSDSKTNFIP KELIEARSQL ISFNPTFKIH ELFAKSTKLK QIIAKIKSDL
     EVEANENAKM KAKLGPSWTL SDSLEFAAPY QSELNNYLKT LAEASATDSA ISQQYALVKD
     DVETLCNSSK ISALLESSIS STDNSGQSLL DIPIEQEEQE RDMKIQLDLL EELQSRVQKL
     VPERQTTLQA LQQKCLQDDI SESLMQNSKR KDSALDTNQL FELELKKFDP LRNRLHASYR
     QQQLLLNEMR NVTQKLKQNP EFLRKMEVYN NQFSKNKELC SNLLSSSLTA KAISEGVSKG
     LEYYKTVEQR LAEINKTLGE QLLLRRKQGA TCLSKLSSSS SSHTSISSNM RNLHI
 
 
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