位置:首页 > 蛋白库 > BRO1_YARLI
BRO1_YARLI
ID   BRO1_YARLI              Reviewed;         867 AA.
AC   Q6CGJ5;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Vacuolar protein-sorting protein BRO1;
DE   AltName: Full=BRO domain-containing protein 1;
GN   Name=BRO1; OrderedLocusNames=YALI0A18766g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in concentration and sorting of cargo proteins of
CC       the multivesicular body (MVB) for incorporation into intralumenal
CC       vesicles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRO1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382127; CAG84150.1; -; Genomic_DNA.
DR   RefSeq; XP_500217.1; XM_500217.1.
DR   AlphaFoldDB; Q6CGJ5; -.
DR   SMR; Q6CGJ5; -.
DR   STRING; 4952.CAG84150; -.
DR   EnsemblFungi; CAG84150; CAG84150; YALI0_A18766g.
DR   GeneID; 2906507; -.
DR   KEGG; yli:YALI0A18766g; -.
DR   VEuPathDB; FungiDB:YALI0_A18766g; -.
DR   HOGENOM; CLU_003661_0_0_1; -.
DR   InParanoid; Q6CGJ5; -.
DR   OMA; ANHKQSA; -.
DR   Proteomes; UP000001300; Chromosome A.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR   Gene3D; 1.25.40.280; -; 1.
DR   InterPro; IPR025304; ALIX_V_dom.
DR   InterPro; IPR045251; BRO1-like.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   PANTHER; PTHR23030; PTHR23030; 2.
DR   Pfam; PF13949; ALIX_LYPXL_bnd; 1.
DR   Pfam; PF03097; BRO1; 1.
DR   SMART; SM01041; BRO1; 1.
DR   PROSITE; PS51180; BRO1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Endosome; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..867
FT                   /note="Vacuolar protein-sorting protein BRO1"
FT                   /id="PRO_0000218871"
FT   DOMAIN          1..412
FT                   /note="BRO1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT   REGION          778..867
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        778..844
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   867 AA;  96484 MW;  EF84C7FC0F4683C4 CRC64;
     MIPLALKTTE STDWSRAIHR YIASSYGPDY AEQFREEISS FQRLRQDIRG AGRDATGRDI
     LFRYFAQLDS LERRINAAES GMKPDFTWSD SLSQEKVTQH SISFEKANVL YQLGAILSCM
     GEEMSRDDSC DPKASFHAFQ NAAGVFAFIA DKFLHAPLPD IGQDVVRAFN KLMLAQAQEM
     FCQDSIAKSV SVLTDVNQEQ AGKVSALTAK LCAGVGALYK AAFESFTAIQ EEQKWGDKNW
     PLECQGKNKY FTALGSLLYA KSLQNKPSTQ KFGESIGYIQ KSINEFNEAS MLPLPNGANK
     KDFNKWYRDL VSTALDLARS TLKSSEHDND LIYHSLVPAP ATLGAVEPKE VVTATPLQDM
     YKEEDHVRVV GRDLFTRLVP MHVLQQTSVY SEEKASLLRS EGERIEVADQ KLNSALEYMG
     LPGELYALKK DLQSGRDSGS SAQVPAVVLG YASEVKTLDL SPLKTSRDQI LTQIRDSQAL
     IASEETESTK MKDYYKDGWT QAPSAQVNAS LLSDIRRVQE SLVAAGASDE KLQAQYDGVK
     PDIELLSRGI NNPELEKLFD ADSSSSKSSS GPSESLIDLD FSQGAASRDP AASSTLDKLL
     PSCETSFRKL QNCQKDRQAI FYEFKDKVHR DDISGVLVNS KGADDNLIFE QELEKFQPYQ
     QRLTATINTQ ALLIKDLADS WEKITRDPVV KNKVTDRKRA LDHSHVIVER FRKAFESWKQ
     VKTGLDKGLE FYRDLQNMAD KVNVSATQFV NARRQEGKSI LSAIQSNTTN ELQSQLGRLS
     FGSGSSSAAP TSGGAPTLPP KPQQHTGDNY GQPSTYDPSV YGPNSPFMQQ PPQHQQYGQP
     PHHQQYGQNP PPPPQGANQN QFWNQYR
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024