BRO1_YARLI
ID BRO1_YARLI Reviewed; 867 AA.
AC Q6CGJ5;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Vacuolar protein-sorting protein BRO1;
DE AltName: Full=BRO domain-containing protein 1;
GN Name=BRO1; OrderedLocusNames=YALI0A18766g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in concentration and sorting of cargo proteins of
CC the multivesicular body (MVB) for incorporation into intralumenal
CC vesicles. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BRO1 family. {ECO:0000305}.
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DR EMBL; CR382127; CAG84150.1; -; Genomic_DNA.
DR RefSeq; XP_500217.1; XM_500217.1.
DR AlphaFoldDB; Q6CGJ5; -.
DR SMR; Q6CGJ5; -.
DR STRING; 4952.CAG84150; -.
DR EnsemblFungi; CAG84150; CAG84150; YALI0_A18766g.
DR GeneID; 2906507; -.
DR KEGG; yli:YALI0A18766g; -.
DR VEuPathDB; FungiDB:YALI0_A18766g; -.
DR HOGENOM; CLU_003661_0_0_1; -.
DR InParanoid; Q6CGJ5; -.
DR OMA; ANHKQSA; -.
DR Proteomes; UP000001300; Chromosome A.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR Gene3D; 1.25.40.280; -; 1.
DR InterPro; IPR025304; ALIX_V_dom.
DR InterPro; IPR045251; BRO1-like.
DR InterPro; IPR004328; BRO1_dom.
DR InterPro; IPR038499; BRO1_sf.
DR PANTHER; PTHR23030; PTHR23030; 2.
DR Pfam; PF13949; ALIX_LYPXL_bnd; 1.
DR Pfam; PF03097; BRO1; 1.
DR SMART; SM01041; BRO1; 1.
DR PROSITE; PS51180; BRO1; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Endosome; Protein transport; Reference proteome; Transport.
FT CHAIN 1..867
FT /note="Vacuolar protein-sorting protein BRO1"
FT /id="PRO_0000218871"
FT DOMAIN 1..412
FT /note="BRO1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT REGION 778..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 96484 MW; EF84C7FC0F4683C4 CRC64;
MIPLALKTTE STDWSRAIHR YIASSYGPDY AEQFREEISS FQRLRQDIRG AGRDATGRDI
LFRYFAQLDS LERRINAAES GMKPDFTWSD SLSQEKVTQH SISFEKANVL YQLGAILSCM
GEEMSRDDSC DPKASFHAFQ NAAGVFAFIA DKFLHAPLPD IGQDVVRAFN KLMLAQAQEM
FCQDSIAKSV SVLTDVNQEQ AGKVSALTAK LCAGVGALYK AAFESFTAIQ EEQKWGDKNW
PLECQGKNKY FTALGSLLYA KSLQNKPSTQ KFGESIGYIQ KSINEFNEAS MLPLPNGANK
KDFNKWYRDL VSTALDLARS TLKSSEHDND LIYHSLVPAP ATLGAVEPKE VVTATPLQDM
YKEEDHVRVV GRDLFTRLVP MHVLQQTSVY SEEKASLLRS EGERIEVADQ KLNSALEYMG
LPGELYALKK DLQSGRDSGS SAQVPAVVLG YASEVKTLDL SPLKTSRDQI LTQIRDSQAL
IASEETESTK MKDYYKDGWT QAPSAQVNAS LLSDIRRVQE SLVAAGASDE KLQAQYDGVK
PDIELLSRGI NNPELEKLFD ADSSSSKSSS GPSESLIDLD FSQGAASRDP AASSTLDKLL
PSCETSFRKL QNCQKDRQAI FYEFKDKVHR DDISGVLVNS KGADDNLIFE QELEKFQPYQ
QRLTATINTQ ALLIKDLADS WEKITRDPVV KNKVTDRKRA LDHSHVIVER FRKAFESWKQ
VKTGLDKGLE FYRDLQNMAD KVNVSATQFV NARRQEGKSI LSAIQSNTTN ELQSQLGRLS
FGSGSSSAAP TSGGAPTLPP KPQQHTGDNY GQPSTYDPSV YGPNSPFMQQ PPQHQQYGQP
PHHQQYGQNP PPPPQGANQN QFWNQYR